Synthesis and anticonvulsant evaluation of some new 2,3,8-trisubstituted-4(3H)-quinazoline derivatives

Synthesis, antitumor and antimicrobial activity of some new 6-methyl-3-phenyl-4(3H)-quinazolinone analogues: in silico studies

“…Such medical health problems have encouraged many medicinal chemists to search for novel antibacterial agents other than the analogs of existing antibiotics 7 . Quinazolines are frequently used in medicine because of their wide spectrum of biological activities [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] . Based on the good performances of quinazoline derivatives in anticancer application, development of novel quinazoline derivatives as anticancer drugs is a promising field 9 .…”

Novel quinazoline and pyrido[2,3-d]pyrimidine derivatives and their hydroselenite salts as antitumoral agents

“…Quinazoline derivatives have been utilized extensively in medicinal chemistry due to its privileged structure that shows various pharmacological activities, such as antifungal, 1 antibacterial, 2 anti-inflammatory, 3 anticonvulsant 4 , antihypertensive 5 and anticancer activities [6][7][8] among others. This scaffold has been identified as new class of cancer chemotherapeutic agents acting as potent inhibitors for epidermal growth factor receptor (EGFR), 9 or dihydrofolate reductase.…”

Design, Synthesis, Computer Modeling and Analgesic Activity of Some New Disubstituted Quinazolin-4(3H)-ones

“…The solid product was obtained crystallized from ethanol 95% to afford the desired products VII 1-4 . Synthesis of substituted-2-Benzylamino-3-(substituted benzylidene amino) quinazolin-4(3H)-one VIII [1][2][3][4][5][6][7][8][9][10][11][12] General procedure: A mixture of 3-amino-2-benzylamino substituted quinazolin-4(3H)-one VII 1-4 (0.01 mol) and different aromatic aldehydes derivative (0.01 mol) in acetic acid was refluxed for 30 hrs. After completion of reaction (TLC) the reaction mixture was poured into crushed ice and the solid obtained was crystallized from ethanol 95% to obtain pure compounds VIII 1-12 .…”

“…Quinazolines derivatives exhibited a vital role in many pharmacological activities [1][2][3][4][5][6][7][8] including anti-inflammatory, [9] antibacterial, [10] and anticonvulsant, [11] activities. Schiff 's bases have generated a great deal of attention due to their interesting pharmaceutical activities include possess potent analgesic and antiinflammatory activities [12].…”