Synthesis and antidiabetic properties of chitosan-stabilized selenium nanoparticles

Zeng, Siqi; Yu, Ke; Liu, Yixi; Shen, Yingbin; Zhang, Lan; Li, Cheng; Liu, Aiping; Shen, Lihua; Hu, Xinjie; Wu, Hejun; Wu, Wenjing; Liu, Yuntao

doi:10.1016/j.colsurfb.2018.06.003

Cited by 70 publications

(40 citation statements)

References 35 publications

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“…The organic compounds or the biomolecules in the extract are responsible for the reduction and stabilization of the nanoparticles by preventing the aggregation of the nanoparticle [34]. Similar results were obtained for SeNPs synthesized using E. coli ATCC 35218 as reported by Kora and Rastogi [35], chitosan-coated SeNPs also gave uniform spherical morphology reported by Zeng et al [36] and SeNPs coated with Clausena dentata plant leaf extract reported by Sowndarya et al [37].…”

Section: Electron Microscopysupporting

confidence: 70%

Catalytical degradation of industrial dyes using biosynthesized selenium nanoparticles and evaluating its antimicrobial activities

Menon

Agarwal

Shanmugam

2021

Sustain Environ Res

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The release of textile dyes from the industries to the environment has become a significant health issue to humans and their surroundings, where a large number of dyes are wasted to the nearby water during the dyeing process. Therefore, the practice of the utilization of biosynthesized nanoparticles from numerous biological systems has been described, out of which plant material is considered the most appropriate method. The usage of plant material not only makes the procedure ecological but also their abundance makes it more cost-effective. The present study aims to biologically produce selenium nanoparticle using Mucuna pruriens seed powder and apply it in the degradation of dyes and removal of pathogenic bacterial cultures from pathogen-containing lake water using an optimum concentration of selenium nanoparticles. The production of selenium nanoparticles was characterized via visual coloration from colorless to brown solution which was checked using UV–Visible spectrophotometer, the crystalline structure was analyzed using X-ray diffraction, the morphology was analyzed with transmission electron microscopy, scanning electron microscopy, dynamic light scattering, which was in the range of 90–120 nm, with stable spherical monodisperse characteristics. The surface potential was checked using zeta potential, while the Atomic Force Microscopy gave information on the roughness of the nanoparticles, and the presence of –OH, −COO, aromatic groups were confirmed with Fourier Transform Infrared spectroscopy. The biosynthesized nanoparticles were then analyzed for its environmental applications, like degradation of dyes from industrial wastes and checking its antimicrobial activities.

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Section: Electron Microscopysupporting

confidence: 70%

Catalytical degradation of industrial dyes using biosynthesized selenium nanoparticles and evaluating its antimicrobial activities

Menon

Agarwal

Shanmugam

2021

Sustain Environ Res

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“…As demonstrated previously, T2DM is often accompanied by abnormalities in serum lipid profiles. Thus, T2D therapies are aimed to prevent dyslipidemia, which characterized by elevated serum levels of TG, TC, LDL-c, total lipids and decreased serum levels of HDL-c [22]. In the present study, a marked disorder in serum lipid profiles was observed in HFD/STZ-induced diabetic rats (Table 5).…”

Section: Discussionsupporting

confidence: 51%

“…Furthermore, Liu et al, illustrated the administration of CVPs-Se-NPs ameliorated the blood sugar, body weight, oxidative stress and dyslipidemia in STZ-induced diabetic mice [21]. Additionally, CTS-Se-NPs at dose 2 mg/kg exhibited a strong anti-diabetic activity in STZ-induced diabetic mice by enhancing body weight, decreasing glucose and insulin levels, decreasing serum lipid profile, and improving antioxidant status [22]. Moreover, the treatment of STZ-induced rats by liposomal-Se-NPs for 21 days results in a marked decline in glucose level with a marked increase in serum insulin and pancreatic antioxidant [23].…”

Section: Introductionmentioning

confidence: 99%

Synergistic effect of nano-selenium and metformin on type 2 diabetic rat model: Diabetic complications alleviation through insulin sensitivity, oxidative mediators and inflammatory markers

Abdulmalek

Balbaa

2019

PLoS ONE

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Background and objectives In the present article, we explore a novel strategy of selenium nanoparticles (Se-NPs) for the treatment of type 2 diabetes mellitus (T2DM) by investigating the effect of Se-NPs alone and in combination with standard anti-diabetic drug metformin (MET) in high-fat diet/streptozotocin (HFD/STZ)-induced T2DM. Methods HFD was supplemented daily to experimental rats for 8 weeks, followed by a single low dose injection of 35 mg/kg of STZ to induce T2DM. The synergistic effect of the different therapeutic strategies on diabetic complications was evaluated after the Se-NPs and MET administration for 8 weeks. Molecular and biochemical analyses were conducted to figure out the effectiveness of our treatment on insulin sensitivity, oxidative mediators and inflammatory markers. Results Our observations demonstrated that HFD/STZ-induced rats have a toxic effect on serum and hepatic tissues resulted in inducing remarkable oxidative damage and hyper-inflammation with a significant disturbance in the insulin signaling pathway. Experimental animals either treated with mono-therapeutic-two doses Se-NPs (0.1 and 0.4 mg/kg) and/or MET (100 mg/kg) alone as well as the combined therapy resulted in a remarkable protective anti-diabetic effect illustrated by significant decreases in fasting blood glucose and insulin levels after 8 weeks treatment. At the same time, the levels of active insulin signaling proteins pIRS1/pAKT/pGSK-3β/pAMPK were significantly improved. Moreover, Se-NPs exhibited an anti-inflammatory effect by the mitigation of cytokine expression and a balance between oxidative stress and antioxidant status was restored. Furthermore, the anti-diabetic drug MET administration also exhibited a significant improvement in diabetic complications after the treatment period. Conclusion This study provides mightily the mechanism of action of combined Se-NPs and MET as a promising therapeutic alternative that synergistically alleviates most of diabetic complications and insulin resistance.

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“…Furthermore, chitosan oligosaccharide has been applied for drug delivery system in diabetes. For instance, chitosan-microcapsulated insulin, chitosan-stabilized selenium nanoparticles, chitosan encapsulated resveratrol, chitosan coating of TiO 2 nanotube arrays for metformin, chitosan nanoparticle and chitosan hydrogel were used for improving diabetic therapy [ 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 ]. Interestingly, the development of chitosan oligosaccharide as a drug or supplement for diabetic treatment has been studied for a decade.…”

Section: Potential Applications Of Chitin and Chitosan Oligosacchamentioning

confidence: 99%

Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications

Satitsri

Muanprasat

2020

Molecules

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Chitin is a long-chain polymer of N-acetyl-glucosamine, which is regularly found in the exoskeleton of arthropods including insects, shellfish and the cell wall of fungi. It has been known that chitin can be used for biological and biomedical applications, especially as a biomaterial for tissue repairing, encapsulating drug for drug delivery. However, chitin has been postulated as an inducer of proinflammatory cytokines and certain diseases including asthma. Likewise, chitosan, a long-chain polymer of N-acetyl-glucosamine and d-glucosamine derived from chitin deacetylation, and chitosan oligosaccharide, a short chain polymer, have been known for their potential therapeutic effects, including anti-inflammatory, antioxidant, antidiarrheal, and anti-Alzheimer effects. This review summarizes potential utilization and limitation of chitin, chitosan and chitosan oligosaccharide in a variety of diseases. Furthermore, future direction of research and development of chitin, chitosan, and chitosan oligosaccharide for biomedical applications is discussed.

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Synthesis and antidiabetic properties of chitosan-stabilized selenium nanoparticles

Cited by 70 publications

References 35 publications

Catalytical degradation of industrial dyes using biosynthesized selenium nanoparticles and evaluating its antimicrobial activities

Catalytical degradation of industrial dyes using biosynthesized selenium nanoparticles and evaluating its antimicrobial activities

Synergistic effect of nano-selenium and metformin on type 2 diabetic rat model: Diabetic complications alleviation through insulin sensitivity, oxidative mediators and inflammatory markers

Chitin and Chitosan Derivatives as Biomaterial Resources for Biological and Biomedical Applications

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