Synthesis and Antifungal Activity of Aspirin Derivatives

Abstract

Sclerotinia sclerotiorum, Helminthosprium maydis, Botrytis cinerea and Rhizoctonia solani are harmful pathogenic fungi of crops or vegetables 1-4. Over the past decades, synthetic fungicides including carbendazim have been used to prevent them. However, in recent years, they have developed resistance to the fungicides 5-9. Moreover, their scope of resistance continues to expand and has already included many new fungicides 10-12. Therefore, new fungicides are continually required. It is well-known that since aspirin (acetylsalicylic acid) was first marketed in 1899, it has been widely used for the treatment of pains, fever and colds 13-16. Therefore, in the present study, aspirin derivatives were synthesized based on aspirin. In the meantime, their antifungal activity has been evaluated in the laboratory to find new fungicides with high efficacy and low toxicity.

Synthesis, crystal structure and in vitro anti-proliferative activity of 2-[(4-acetylphenyl)carbamoyl]phenyl acetate

“…1). The chemical identity of the product was confirmed by various spectroscopic techniques consistent with literature reports (Gao et al, 2014;Eissa et al, 2017).…”

Recent advances in the synthesis of nitrogen heterocycles via radical cascade reactions using isonitriles as radical acceptors

“…Mechanistic studies on these reactions revealed that P-centered radicals are involved in these transformations and the mechanism is similar to the one suggested in Scheme 10b. [22][23][24] Scheme 8 6-Arylated phenanthridines via visible-light-induced radical arylation of isonitriles.…”

Recent advances in sulfur- and phosphorous-centered radical reactions for the formation of S–C and P–C bonds

“…The Tang and Zhao group reported Mn(OAc) 3 -promoted phosphonyl radical reactions of 2-isocyanobiaryls 367 for the synthesis of 6-phenanthrinephosphonates 368 (Scheme 156) 256. In the presence of radical initiators or oxidants, phosphinic acids as well as phosphinates and their salts can be used for the generation of hydrophosphonyl radicals.…”