Synthesis and antifungal activity of novel 2‐benzimidazolylimino‐5‐arylidene‐4‐thiazolidinones

Mobinikhaledi, Akbar; Foroughifar, Naser; Kalhor, Mehdi; Mirabolfathy, M.

doi:10.1002/jhet.264

Cited by 63 publications

(37 citation statements)

References 21 publications

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“…In view of this report and also due to our attention in one-pot synthesis of organic compounds 23,24 , we are going to describe a practical and more economical method for large-scale preparation of APPs herbicides 1-12.…”

Section: Introductionmentioning

confidence: 99%

A NEW METHOD FOR ONE-POT SYNTHESIS OF ARYLOXYPHENOXYPROPIONATE HERBICIDES USING 2,4,6-TRICHLORO-1,3,5-TRIAZINE AND (n-BU)4NI AS A HOMOGENEOUS CATALYST

Kalhor

Dadras

Mobinikhaledi

et al. 2011

J. Chil. Chem. Soc.

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The one-pot reaction of halo-heterocycle, (R)-4-hydroxyphenoxy propionic acid and an alcohol, amine or sulfonamide is described as an efficient method for the synthesis of aryloxyphenoxy propionate hrerbicides by using 2,4,6-trichloro-1,3,5-triazine in the presence of ( n-Bu) 4 NI, as a homogeneous catalyst under mild conditions. The present procedure offers several advantages, such as good yields, short reaction times and easy workup.

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Section: Introductionmentioning

confidence: 99%

A NEW METHOD FOR ONE-POT SYNTHESIS OF ARYLOXYPHENOXYPROPIONATE HERBICIDES USING 2,4,6-TRICHLORO-1,3,5-TRIAZINE AND (n-BU)4NI AS A HOMOGENEOUS CATALYST

Kalhor

Dadras

Mobinikhaledi

et al. 2011

J. Chil. Chem. Soc.

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“…The five-membered nitrogen containing heterocyclic compounds continue to play an important role in medicinal chemistry [28]. Each year, a large number of drug candidates which contain heterocyclic ring are synthesized by researchers [29].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Antioxidant, Xanthine Oxidase and Urease Inhibitory Activities of Some Chlorine Containing Benzimidazoles

Baltaş¹,

Yılmaz²,

Menteşe³

2016

HJBC

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Ö Z E T B ir seri tetra-substitüe benzimidazol türevi sentezlendi ve üreaz inhibisyon, anti-ksantin oksidaz (XO) ve antioksidan aktiviteleri incelendi. Bazı bileşiklerin önemli derecede antioksidan aktivite gösterdiği tespit edildi. Özellikle, bileşik 4, 5a, 5b, 5c, 5d ve 6b ABTS•+ radikal katyon temizleme (SC 50 : 9.51-70.43 µg/mL) ve bakır indirgeyici antioksidan kapasite (CUPRAC) tayininde yüksek derecede aktivite gösterdiği belirlendi. Bileşik 6d ise, 125 µg/mL derişimde en yüksek anti-ksantin oksidaz (XO) aktivitesi gösterdi. Bütün bileşikler Jack Bean üreaz aktivite tayin yöntemine göre incelendi ve en aktif üreaz inhibisyonuna sahip bileşiğin 7.41±0.13 µg/mL IC 50 değeriyle (5b) olduğu tespit edildi. Anahtar KelimelerÜreaz, ksantin oksidaz, enzim inhibisyon, antioksidan aktivite, benzimidazol. A B S T R A C TA series of tetra-substitued benzimidazole derivatives were synthesized and screened for their urease inhibition, anti-xanthine oxidase (XO) and antioxidant activities. Some of them were found to possess significant antioxidant activity, especially, compounds 4, 5a, 5b, 5c, 5d and 6b exhibited highly scavenging activity in ABTS•+ radical cation decolorization assay (SC 50 : 9.51-70.43 µg/mL) and cupric reducing antioxidant capacity (CUPRAC) assay. Compound 6d exhibited the highest XO inhibition at 125 µg/mL. All compounds were evaluated with regard to Jack Bean urease activity and the most active compound concerning urease enzyme inhibition was (5b), with an IC 50 value of 7.41±0.13 µg/mL.

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“…On the other hand, benzimidazole derivatives also exhibit a broad spectrum of biological activities, such as antifungal, 7) antibacterial, 8) antiviral, 9) antitumor 10) and antiparasitic 11) activities, which are important substances in agricultural and pharmaceutical elds. Among benzimidazole fungicides, carbendazim, benomyl and thiabendazole are still used in fungicide market due to their high e ciency, broad spectrum and good systemic property.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and antifungal activity of novel 2,5-disubstituted-1,3,4-oxadiazoles containing benzimidazole moiety

Zhang

et al. 2012

J. Pestic. Sci.

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Eighteen novel compounds of 2,5-disubstituted-1,3,4-oxadiazoles containing benzimidazole moiety were synthesized from 1H-benzimidazole-2-carbohydrazide, carbon disul de and alkyl halide or benzyl halide by multi-step reactions. e structures of the target compounds were conrmed by IR, 1 H-NMR spectra and elemental analyses. Preliminary antifungal activities against Botrytis cinerea and Sclerotinia sclerotiorum were also evaluated by the mycelium growth rate method, and the results indicated that many target compounds possess excellent antifungal activity, even higher than the control fungicide (carbendazim).

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Synthesis and antifungal activity of novel 2‐benzimidazolylimino‐5‐arylidene‐4‐thiazolidinones

Cited by 63 publications

References 21 publications

A NEW METHOD FOR ONE-POT SYNTHESIS OF ARYLOXYPHENOXYPROPIONATE HERBICIDES USING 2,4,6-TRICHLORO-1,3,5-TRIAZINE AND (n-BU)4NI AS A HOMOGENEOUS CATALYST

A NEW METHOD FOR ONE-POT SYNTHESIS OF ARYLOXYPHENOXYPROPIONATE HERBICIDES USING 2,4,6-TRICHLORO-1,3,5-TRIAZINE AND (n-BU)4NI AS A HOMOGENEOUS CATALYST

Synthesis, Antioxidant, Xanthine Oxidase and Urease Inhibitory Activities of Some Chlorine Containing Benzimidazoles

Synthesis and antifungal activity of novel 2,5-disubstituted-1,3,4-oxadiazoles containing benzimidazole moiety

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