Synthesis and Antifungal Activity of Novel 1,2,4‐Triazole Derivatives Containing 1,2,3‐Thiadiazole Moiety

Abstract

Starting from carbonic acid diethyl ester, a series of 1,2,4‐triazole derivatives containing 1,2,3‐thiadiazole were synthesized. Reactions were performed by microwave irradiation or ultrasonic irradiation as well as by conventional heating. The structure of title compounds was characterized by 1H‐NMR, MS, and elemental analyses. The fungicidal activities of these compounds were tested in vivo. Most of title compounds exhibited good antifungal activity against Pseudoperonospora cubensis. Some of title compounds displayed moderate antifungal activities against Fusarium oxysporum, Pseudoperonospora cubensis, Sphaerotheca fuligenea, Corynespora cassiicola, and Xanthomonas axonopodis.

Synthesis, Crystal Structure and DFT Studies of 8-chloro-3-((3-chlorobenzyl)thio)-[1,2,4]triazolo[4,3-a]pyridine

“…1,2,4-Triazole compounds are classic nitrogen containing heterocycles [1,2]. They display antifungal [3][4][5], herbicidal [6,7], anti-mycobacterial [8] and antioxidant activities [9]. Pyridine is another important nitrogen-containing heterocycle with various bioactivities [10][11][12][13].…”

Design, Synthesis, and Evaluation of 3‐Aryl‐4‐pyrrolyl‐maleimides as Glycogen Synthase Kinase‐3β Inhibitors

“…A mixture of 4 (2.0 g, 7.9 mmol), morpholine (6.9 g, 79.0 mmol), and potassium carbonate (1.9 g, 13.8 mmol) in DMF (30 mL) was stirred at 508C for 6 h [29][30][31][32][33][34][35][36][37]. After cooling, the mixture was poured into cold water (200 mL) and extracted with ethyl acetate (3 Â 100 mL).…”

“…For experiments, cells were grown in 12-well plates until $80% confluence, serum-deprived for 12 h, incubated with GSK-3b inhibitors for 1 h and Ab [25][26][27][28][29][30][31][32][33][34][35] (amyloid beta peptide 25-35, Sigma) for another 6 h. Cells were rinsed twice with ice-cold PBS and lysed with 1Â SDS loading buffer. Cells were cultured in 1:1 DMEM/Ham's F12 containing 10% v/v fetal bovine serum (HyClone), 1% penicillin, and 1% streptomycin at a humidified atmosphere with 5% CO 2 .…”

Synthesis and Evaluation of Some Newly Triazolylindole Derivatives for Antifungal Activity

“…Indole and their derivatives possess broad spectrum of biological activity in both medicinal and pharmaceutical, such as antifungal [1][2][3] , anticancer 4 , antimicrobial 5 , antipsychotic 6 and anticonvulsant 7 etc. The triazole moiety is a versatile lead molecule in pharmaceutical development and has a wide range of biological activities like antifungal [8][9][10] , antimicrobial 11 , anticonvulsant 12 , anti-inflammatory 13 and antihelmintic 14 etc. As these two heterocycles are potent as biologically active compound, in the present study we are planned to prepared new compounds containing both indole derivatives fused with triazole ring and hope to possess better antifungal activity.…”