Synthesis and Antifungal Activity of Some Novel Coumarin‐Amino Acid Conjugates

Abstract

A series of novel coumarin-amino acid conjugates was synthesized and structural characterization was done by various spectroscopic methods. All the conjugates were screened for their antifungal activity against five fungal strains namely T. rubrum, A. niger, A. fumigatus, A. flavus and C. albicans by twofold serial microdilution method. Some of them showed significant activity with MIC values in the range of 6.25-25 μg/ mL. Notably, compound 5 e showed potential antifungal effect against three tested strains with MIC's in the range of 6.25-12.5 μg/mL. The molecular docking studies showed that some conjugates possessed good binding affinity with the modelled receptor of integrin-like protein of Cryptococcus neoformans var. grubii. Compounds 5 d and 5 e also exhibited good binding efficiency with the Candida spp. cell wall associated proteins in in vitro binding assay. Additionally, in silico physicochemical parameters such as lipophilicity and pharmacokinetic properties such as absorption, distribution, metabolism, and excretion (ADME) of the synthesized compounds were also evaluated.

Catalytic Chemical Vapor Deposition Methodology for Carbon Nanotubes Synthesis

“…The SWNTs are synthesized from virgin LD‐PE and PP plastics [105] . LD‐PE and PP are pyrolyzed at between 370 to 550 °C ranges, [105–115] which is determined by TGA. The high quality of the SWNTs was found with an oxidation peak at 588 °C while the oxidation of graphite flakes that a shoulder peak between 400 to 500 °C, which encapsulates the MgO supported by a catalyst‐free approach during the CVD process.…”

Antimicrobial, Antiproliferative Effects and Docking Studies of Methoxy Group Enriched Coumarin‐Chalcone Hybrids

“…They are generally mentioned with various biological effects such as antimicrobial, [5] anticancer, [6] antiviral, [7] anti‐malarial, [8] anti‐leishmanial, [9] and enzyme inhibitory [10] activities. In addition, coumarins are a different type of biologically active organic structures having oxygen‐containing heterocycles and are used in typical human diseases such as cancer, [11] viral, [12] bacterial [13] /fungal infections, [14] tuberculosis, [15] blood coagulation, [16] and malaria [17] . These compounds also show significant biological or pharmacological activities such as antioxidant, [18] antidiabetic, [19] anti‐HIV, [20] anti‐inflammatory, [21] hepatoprotective [22] etc.…”