Synthesis and antifungal activity of cholesterol-hydrazone derivatives

Loncle, Céline; Brunel, Jean Michel; Vidal, Nicolás; Dherbomez, Michel; Letourneux, Yves

doi:10.1016/j.ejmech.2004.07.005

Cited by 248 publications

(120 citation statements)

References 22 publications

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“…Hydrazones are an emerging class of materials, which have been demonstrated to possess awide range of biological and pharmaceutical activities such as antimicrobial, anti-convulsant, antifungal,anticancer, antitubercular, antiviral,antibacterial, and antioxidant activities [1][2][3][4][5][6][7][8].M eanwhile,h ydrazones have also interesting properties because of the presence of several coordinations ites,a nd thus theirm etal complexes are important for their possible biological applications [9].T he thiazole ring is present in various biologically active molecules. Thiazoles and their derivatives possessa ctivities such as antitumor, antiviral, and antibacterial [10][11][12].…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of benzylthiazolo[5,4-b]pyridin-2-yl-diazene, C13H10N4S

Zhang

2015

Zeitschrift Für Kristallographie - New Crystal Structures

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Section: Discussionmentioning

confidence: 99%

Crystal structure of benzylthiazolo[5,4-b]pyridin-2-yl-diazene, C13H10N4S

Zhang

2015

Zeitschrift Für Kristallographie - New Crystal Structures

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“…Hydrazones are an emerging class of materials, which have been demonstrated to possess a wide range of biological and pharmaceutical activities such as antimicrobial [1], anti-convulsant [2], antifungal [3], anticancer [4], antitubercular [5], antiviral [6], antibacterial [7], and antioxidant [8] activities. Meanwhile, hydrazones have also interesting properties because of the presence of several coordination sites, and thus their metal complexes are important for their possible biological applications [9].…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of 1-(propan-2-ylidene)-2-(thiazolo[5,4-b]pyridin-2-yl)- hydrazine, C9H10N4S

Guo

Miao

2013

Zeitschrift Für Kristallographie - New Crystal Structures

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Source of materialThe title compound was obtained from 2-amin-3-chloropyridine according to the literature method [14]. Single crystals suitable for X-ray diffraction were obtained by crystallization of the title compound from methanol. Experimental detailsAll of the non-hydrogen atoms were refined anisotropically. The hydrogen atoms were assigned with common isotropic displacement factors U iso (H) = 1.2U eq (N and pyridine C), or U iso (H) = 1.5U eq (methyl C) and included in the final refinement by using geometrical restraints, with C-H = 0.93 Å (pyridine) or C-H = 0.96 Å (methyl), and N-H = 0.86 Å. 12]. In this paper we report the synthesis and crystal structure of a novel thiazolehyrazone compound. The asymmetric unit contains one molecule of the title compound, which is constructed by the pyridinethiazole moiety, the hydrazone linker, and the bimethyl moiety. Discussion

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“…This versatility has made hydrazones good polydentate chelating agents that can form a variety of complexes with various transition metals. In recent years, a number of hydrazone compounds have been prepared and investigated for their biological properties such as antibacterial, antifungal, 5 anticonvulsant, 6 anti-inflammatory, 7 antimalarial, 8 analgesic, 9 antiplatelets, 10 antituberculosis, 11 and anticancer activities. 12 Hydrazones also act as herbicides, insecticides, nematocides, rodenticides, and plant growth regulators, and are used as plasticizers and stabilizers for polymers, polymerization initiators, antioxidants, etc.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Crystal Structures, and Antibacterial Activity of a Series of Hydrazone Compounds Derived From 4-Methylbenzohydrazide

Yan¹,

Li²,

Fu³

et al. 2015

J. Chil. Chem. Soc.

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A series of hydrazone compounds, 4-methyl-N'-(4-nitrobenzylidene)benzohydrazide methanol solvate (1), N'-(4-hydroxy-3-nitrobenzylidene)-4-methylbenzohydrazide dimethanol solvate (2), and N'-(3,5-dibromobenzylidene)-4-methylbenzohydrazide (3), derived from 4-methylbenzohydrazide with different benzaldehydes, were synthesized and characterized by physico-chemical methods and single crystal X-ray diffraction. Crystals of the compounds are stabilized by intermolecular hydrogen bonds, as well as π···π stacking interactions. Antibacterial activity of the compounds against Staphylococcus aureus, Escherichia coli, and Klebsielle pneumoniae strains was studied. Compounds 1 and 2 have moderate minimum inhibition concentration values on the tested bacteria strains. Compound 3, with the Br-substituent groups, showed the highest activity on the bacterial strains.

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Synthesis and antifungal activity of cholesterol-hydrazone derivatives

Cited by 248 publications

References 22 publications

Crystal structure of benzylthiazolo[5,4-b]pyridin-2-yl-diazene, C13H10N4S

Crystal structure of benzylthiazolo[5,4-b]pyridin-2-yl-diazene, C13H10N4S

Crystal structure of 1-(propan-2-ylidene)-2-(thiazolo[5,4-b]pyridin-2-yl)- hydrazine, C9H10N4S

Synthesis, Crystal Structures, and Antibacterial Activity of a Series of Hydrazone Compounds Derived From 4-Methylbenzohydrazide

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