2023
DOI: 10.1002/cbdv.202300442
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Synthesis and Antifungal Activity of Curcumol Derivatives

Abstract: To discover novel and effective antifungal candidates, a series of new curcumol derivatives were designed, synthesized, and evaluated their antifungal activity against five phytopathogenic fungi by the mycelium growth rate method. Derivatives c4, c22 and c23 exhibited excellent antifungal activity against Phomopsis sp. with EC50 values of 3.06, 3.07, and 3.16 μM, respectively. Specifically, compound c4 exhibited the strongest antifungal activity against Phomopsis sp., which was 44 times that of pyrimethanil (E… Show more

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Cited by 11 publications
(6 citation statements)
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“…The inoculated PDA plates were incubated at 28±1 °C for 4–6 days. The EC50 was determined for compounds at five different concentrations [26–28] . Based on the test of in vitro antifungal activity, compound C17 against Phomopsis sp .…”
Section: Methodsmentioning
confidence: 99%
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“…The inoculated PDA plates were incubated at 28±1 °C for 4–6 days. The EC50 was determined for compounds at five different concentrations [26–28] . Based on the test of in vitro antifungal activity, compound C17 against Phomopsis sp .…”
Section: Methodsmentioning
confidence: 99%
“…was further tested in vivo on kiwifruit. [29][30][31] Further understanding of the antimicrobial mechanism of compound C17 against Phomopsis sp. was obtained through the effect of extracellular polysaccharides (EPS) produced by Phomopsis sp., [32][33] alteration of Phomopsis sp.…”
Section: Fungimentioning
confidence: 99%
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“…Effect on the Mycelial Morphology and Ultrastructure of P. nicotianae. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were performed for studying effect on the mycelial morphology and ultrastructure of P. nicotianae according to the methods stated in a previous study, 37 and the experimental procedures are described in the Supporting Information.…”
Section: Antifungal Activity Assay In Vivomentioning
confidence: 99%