Synthesis and antifungal evaluation of novel dicyanoderivatives of rhodanine

Abstract

This work describes the synthesis and antifungal evaluation of 5‐arylidene‐(Z)‐2‐(1,1‐dicyanomethylene)‐1,3‐thiazol‐4‐ones 5 obtained from the reaction of 2‐(1,1‐dicyanomethylene)‐1,3‐thiazol‐4‐one 3 and benzaldehydes 4. The starting material 3 was synthesized by a condensation reaction of rhodanine 1 and malononitrile 2. The structures of the obtained products were established by IR, NMR, mass spectrometry, and elemental analysis. J. Heterocyclic Chem., (2011).

Total synthesis of natural products containing benzofuran rings

“…[40][41][42][43][44][45][46][47][48][49][50][51][52][53] Remarkably, a large number of synthetic approaches have been attempted and accomplished for the synthesis of fused benzofurans. The synthesis frequently starting from differently appropriate substituted benzene rings.…”

Microwaves in Heterocyclic Chemistry

“…Munawar et al developed a facile and fast synthesis of 2-pyrazolines in ethanol from a quinolylchalcone and phenylhydrazine in the presence of potassium carbonate or alumina [24]. A similar methodology was extended successively by Insuasty et al [25] and Manna and Agrawal [26] for the preparation of new pyrazoline derivatives for drug discovery programs. Westwood and co-workers conducted extensive investigations on the development of highly functionalized pyridines using Ghosez-type reactions of dihydropyrazoles [27] under microwave irradiation.…”

Synthesis, Characterization and Antimicrobial Activity of Novel Chalcones Analogues

“…Chalcones have been used as intermediate for the preparation of compounds having therapeutic value [5][6][7] . Chalcones and their derivatives, whether synthetic or naturally occurring are an interesting and significant group of molecules as they possess a wide range of pharmacological activities such as anti-inflammatory, antimicrobial, antifungal, antibacterial, antioxidant, cytotoxic antitumor, anticancer, antimitotic, antileishmanial, antimalarial, antitubercular, antiviral and so on [8][9][10][11][12][13][14][15][16][17][18][19][20][21] .…”