Synthesis and antifungal potential of Co(II) complexes of 1-(2′-hydroxyphenyl) ethylideneanilines

Hothi, H.S.; Makkar, Anju; Sharma, Jyoti; Manrao, M. R.

doi:10.1016/j.ejmech.2005.07.016

Cited by 31 publications

(10 citation statements)

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“…When we compare two chemically different group of compounds, namely derivatives of salicylaldehyde (10)(11)(12)(13) and coumarin derivatives (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28) in context of their anticancer activity, we can take some general conclusions. Schiff bases derived from salicylaldehyde are effective in pancreas and cervical cancer cells; however, they demonstrate also…”

Section: Cytotoxicitymentioning

confidence: 99%

Design, synthesis, and biological activity of Schiff bases bearing salicyl and 7-hydroxycoumarinyl moieties

et al. 2019

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18 (11 novel) Schiff bases, derivatives of salicylaldehyde, 2-hydroxyacetophenone, and 6-acetyl-, 8-acetyl-, and 8-formyl-7-hydroxy-4-methylcoumarin were synthesized and characterized by their spectral studies. 6-Acetyl-7-hydroxy-4-methylcoumarin was prepared by novel method under microwave assistance. These Schiff bases were evaluated for antibacterial activities against 12 bacterial and six fungi strains in vitro. N-(3,5-Dichloro-2-hydroxybenzylidene)-4-aminobenzenesulfonic acid sodium salt proved to be the most active against Staphylococcus aureus and MRSA strains (MIC 0.0194 µmol/cm 3). The substitution pattern, two chlorine atoms in the salicylidene ring and the SO 3 Na group, is probably the most beneficial for the activity against Gram-(+) bacteria strains. All Schiff bases were evaluated for cancer efficacy against CFPAC-1 and HeLa cell cultures originating from human pancreas cancer or human cervical cancer. Schiff bases derived from salicylaldehyde are highly effective in pancreas and cervical cancer cells; however, they demonstrate also substantial toxicity towards NIH3T3 cells. Derivatives of coumarin contain three highly selective compounds: 7-hydroxy-8-[(4-methoxyphenylimino)methyl]-4-methyl-2H-chromen-2-one, N-[(7-hydroxy-4-methyl-2-oxo-2H-chromen-8-yl)methylene]-4-aminobenzenesulfonic acid sodium salt, and 7-hydroxy-8-[1-(4-hydroxyphenylimino)ethyl]-4-methyl-2H-chromen-2-one suggesting more promising potential of the second group of substances.

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Section: Cytotoxicitymentioning

confidence: 99%

Design, synthesis, and biological activity of Schiff bases bearing salicyl and 7-hydroxycoumarinyl moieties

et al. 2019

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“…It has also been found that in general the complexation of schiff bases with iron, copper, zinc and other metals also influences their antifungal activity. Makkar et al found that cobalt complex of ethylideneaniline 115 gave moderate antifungal activity against A. alternata, F. oxysporum and M. roridum [213] . Acylhydrazones constitute an interesting class of chelating agents, their metal complexes may have potential use in the biological fields.…”

Section: Supermolecules As Antifungal Agentsmentioning

confidence: 99%

Review on supermolecules as chemical drugs

Zhou

Gan

Zhang

et al. 2009

Sci. China Ser. B-Chem.

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Supramolecular medicinal chemistry field has been a quite rapidly developing, increasingly active and newly rising interdiscipline which is the new expansion of supramolecular chemistry in pharmaceutical sciences, and is gradually becoming a relatively independent scientific area. Supramolecular drugs could be defined as medicinal supermolecules formed by two or more molecules through noncovalent bonds. So far a lot of supermolecules as chemical drugs have been widely used in clinics. Supermolecules as chemical drugs, i.e. supramolecular chemical drugs or supramolecular drugs, which might have the excellences of lower cost, shorter period, higher potential as clinical drugs for their successful research and development, may possess higher bioavailability, better biocompatibility and drug-targeting, fewer multidrug-resistances, lower toxicity, less adverse effect, and better curative effects as well as safety, and therefore exhibit wide potential application. These overwhelming advantages have drawn enormous special attention. This paper gives the definition of supramolecular drugs, proposes the concept of supramolecular chemical drugs, and systematically reviews the recent advances in the research and development of supermolecules, including organic and inorganic complex ones as chemical drugs in the area of antitumor, anti-inflammatory, analgesic, antimalarial, antibacterial, antifungal, antivirus, anti-epileptic, cardiovascular agents and magnetic resonance imaging agents and so on. The perspectives of the foreseeable future and potential application of supramolecules as chemical drugs are also presented.

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“…These Schiff bases exhibit a wide range of biological activities and applications [1][2][3][4][5][6][7]. Cobalt is an important life-required element.…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of azido(2-bromo-4-chloro-6-((2-diethylaminoethylimino) methyl)phenolato)(2-bromo-4-chloro-6-((2-diethylhydrogenaminoethylimino) methyl)phenolato)cobalt(III) nitrate, [Co(C13H17BrClN2O)(C13H18BrClN2O)(N3)][NO3]

Peng¹,

Wu²,

Song³

2007

Zeitschrift Für Kristallographie - New Crystal Structures

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Source of materialAll the chemicals used were of AR grade. N,N-diethyl-1,2-diaminoethane (23.2 mg, 0.2 mmol) and 3-bromo-5-chlorosalicylaldehyde (47.0 mg, 0.2 mmol) were refluxed in 10 ml methanol for 30 min. To the above solution was added NaN 3 (6.5 mg, 0.1 mmol) and Co(NO 3 ) 2 · 6H 2 O (29.0 mg, 0.1 mmol) in 10 ml methanol. The mixture was refluxed for 1 h. The mixture was filtered after cooling to room temperature. After keeping the filtrate in air for 7 d, brown crystals were formed. Experimental detailsH2 was located from a Fourier difference map and refined isotropically, with NH distance restrained to 0.90(1) Å. Other H atoms were positioned geometrically and constrained as riding atoms, with CH distances of 0.93-0.97 Å, and U iso (H) set to 1.2 or 1.5 U eq (C). DiscussionThe condensation reaction of aromatic aldehydes with primary amines has been shown to offer an easy and inexpensive way of forming a variety of Schiff bases. These Schiff bases exhibit a wide range of biological activities and applications [1][2][3][4][5][6][7]. Cobalt is an important life-required element. Many cobalt complexes were prepared and structurally determined by single-crystal X-ray analysis [6][7][8]. We have reported the structure of a mononuclear Schiff base cobalt(III) complex [9] and a mononuclear Schiff base nickel(II) complex [10]. As an extension of the work, we synthesized a further Schiff base cobalt(III) complex. The asymmetric unit of the crystal structure of the title compound is composed of the cationic mononuclear complex molecule [Co(C 13 H 17 BrClN 2 O)(C 13 H 18 BrClN 2 O)(N 3 )] + and a nitrate anion. The Co(III) atom in the complex is coordinated by two Schiff base ligands and one azide ligand, forming an octahedral coordination. One Schiff base ligand coordinates to the metal through one phenolic O, one imine N, and one amine N atoms, while the other one coordinates to the metal through phenolic O and imine N atoms. The azide acts as a terminal ligand and coordinates to the metal through one terminal N atom. The CoO and CoN bond lengths are comparable to the values in other similar complexes [11,12]. The N3Co1N4 bond angle deviates from the ideal value of 90°by 3.9(2)°, which is due to the strain created by the five-membered chelate ring Co1/N3/C21/C22/N4.

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Synthesis and antifungal potential of Co(II) complexes of 1-(2′-hydroxyphenyl) ethylideneanilines

Cited by 31 publications

References 0 publications

Design, synthesis, and biological activity of Schiff bases bearing salicyl and 7-hydroxycoumarinyl moieties

Design, synthesis, and biological activity of Schiff bases bearing salicyl and 7-hydroxycoumarinyl moieties

Review on supermolecules as chemical drugs

Crystal structure of azido(2-bromo-4-chloro-6-((2-diethylaminoethylimino) methyl)phenolato)(2-bromo-4-chloro-6-((2-diethylhydrogenaminoethylimino) methyl)phenolato)cobalt(III) nitrate, [Co(C13H17BrClN2O)(C13H18BrClN2O)(N3)][NO3]

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