Synthesis and antifungal screening of tetramethyl hexahydro-1H-xanthene-1,8(2H)-dione derivatives as potential inhibitors of morphogenesis and biofilm formation inCandida albicans

Abstract

Biofilms formed by the Candida albicans species are very challenging to control as their resistance to existing antifungal drugs and the need for new therapeutic agents to tackle are highly...

Efficient and reusable Pumice supported perchloric acid catalyst for concise and effective synthesis of 1,8-dioxo-octahydroxanthenes under solvent free condition

“…[7][8][9][10] Xanthendione are found as an important core in various natural products. Xanthene and their derivatives have shown crucial antimicrobial, 11 antimycobacterial, 12 antimalerial, 13 anticancer, 14 antihypertensive, 15 antiinflammatory, 16 antifungal, 17 antiplatelet, 18 antioxidant, 19 Many reports are available in the literature for the synthesis of 1,8-dioxo-octahydroxanthene by the condensation reaction of active methylene compounds with aldehydes in the presence of different catalytic materials such as Fe2O3 NPs, 20 TMSCl, 21 Perlite NPs@IL/ZrCl4, 22 β-cyclodextrin grafted with butyl sulfonic acid, 23 ZnS-Fe2O3-Ag Nanocomposite, 24 Barium Perchlorate, 25 TiO2/[(SO4) 2-], 26 thiourea dioxide, 27 FeNP@SBA-15, 28 ZnO NPs, 29 KF/Al2O3 or Silica Sulfate, 30 [HBIM][BF4]/US, 31 Amberlyst-15, 32 Cyanuric chloride, 33 Dowex-50W, 34 p-dodecyl benzene sulphonic acid, 35 SbCl3/SiO2, 36 silica sulphuric acid, 37 HClO4-SiO2, 38 and NaHSO4-SiO2, 39 triethylbenzyl ammonium chloride, 40 p-TSA, 41 etc. Although, in continuation of our investigation in view of the development of new eco-friendly routes for the synthesis of bioactive compounds using a novel less toxic catalyst, 2,3 we describe an effective and rapid method for the synthesis of 1,8-dioxo-octahydroxanthene using recyclable new pumice@HClO4 as a catalyst.…”