Synthesis and antiinflammatory activity of N-[1-(5-R-Oxy-2-methylbenzofuran-3-yl)ethyl]-N-hydroxyureas

Synthesis and pharmacological activity of benzofurylhydroxyureas and benzofurylhydroxamic acids

“…Finally, the precipitate was separated by filtration, washed with acetonitrile and water, and dried in vacuum over sodium hydroxide to obtain 13.07 g (63.2%) of compound II; m.p., 87 -89.5°C (isopropyl alcohol). 1 …”

“…The filtrate was treated with potassium carbonate to pH 7, filtered, evaporated to dryness in vacuum, and purified by chromatography on a column eluted with chloroform to obtain 0.36 g (50.4%) of compound VIa; m.p., 120 -123°C. 1 …”

“…1 N-Hydroxy-N-(2-methyl-5-methoxybenzofuran-3-yl)ethyl]acetamide (VIIa). To a solution of 1.00 g (0.0045 mole) of compound IVa in 20 ml of tetrahydrofuran was added 1.00 ml (0.0072 mole) of triethylamine.…”

“…The residue was washed with water and dried over sodium hydroxide in vacuum to obtain 0.61 g (51.5%) of compound VIIa; m.p., 140 -142.5°C (ethanol -water, 1 : 3). 1 …”

“…Compounds IVa, IVb, Va, and Vb were synthesized as described previously [1]. An analogous scheme was used to obtain methoxycarbonyl derivatives IVc and Vc.…”