Synthesis and antiinflammatory and analgesic activities of quinolino[2,1-b]quinazoline derivatives

Mikhalev, A. I.; Konshin, M. E.; Yanborisova, O. A.; Zaks, A. S.; Yushkov, V. V.

doi:10.1007/bf00768982

Cited by 5 publications

(7 citation statements)

References 2 publications

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“…4(4H)-quinazolines have been tested successfully against cancer and HIV virus [ 5 , 6 ]. The synthetic analogues of quinazolines have been found to exhibit antimalarial [ 7 ], anti-inflammatory [ 8 ], and anticancer activity [ 9 ]. They show potent and specific inhibitory action against leukemia cells [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Study of Newly Synthesized Lanthanide(III) Complexes of 2‐[2‐hydroxy‐3‐methoxyphenyl]‐3‐[2‐hydroxy‐3‐methoxybenzylamino]‐1,2‐dihydroquinazolin‐4(3H)‐one

et al. 2007

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New lanthanide(III) complexes with 2-[2-hydroxy-3-methoxyphenyl]-3-[hydroxyl-3-methoxybenzylamino]-1,2-dihydroquin- azoline-4(3H)-one (Hmpbaq) have been synthesized and characterized by elemental analysis, conductance measurements, magnetic susceptibilities, spectroscopic (IR, NMR, UV, EPR), and thermal studies. Molar conductance studies indicate 1 : 1 electrolytic behavior for these complexes. IR spectra indicate that Hmpbaq acts as a tridentate ligand coordinating through carbonyl oxygen, benzyl amine nitrogen, and deprotonated phenolic oxygen. TG and DTA studies of La(III) and Pr(III) complexes indicate the presence of two coordinated water molecules. Based on these studies, the complexes have been formulated as [La(mpbaq)2(H2O)2]·NO3, where Ln = La(III), Pr(III), Nd(III), Sm(III), Eu(III), Gd(III), Th(III), Dy(III), and Y(III). The ligand, lanthanide(III) salts, and the corresponding complexes have been simultaneously screened for their antibacterial and antifungal activities and compared with the drugs in use.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial Study of Newly Synthesized Lanthanide(III) Complexes of 2‐[2‐hydroxy‐3‐methoxyphenyl]‐3‐[2‐hydroxy‐3‐methoxybenzylamino]‐1,2‐dihydroquinazolin‐4(3H)‐one

et al. 2007

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“…4(3H)-Quinazolines have been tested successfully against cancer and HIV virus [1,2]. The synthetic analogues of quinazolines have been found to exhibit antimalarial [3], antiinflammatory [4], CNS depressant [5] and anticancer activity [6]. They show potent and specific inhibitory action against leukemia cells [7].…”

Section: Introductionmentioning

confidence: 99%

“…Looking into the wide variety of biological and pharmacological activity of the quinazoline derivatives [1][2][3][4][5][6][7][8][9][10], we have synthesized and characterized 1,2-dihydroquinazoline (1) (Scheme 1) and its transition metal(II) complexes, which was reported in our earlier communication [11]. The 1,2-dihydroquinazoline (1), which contains an sp 3 hybridized carbon (C14) in the pyrimidine nucleus makes the quinazoline ring non planar.…”

Section: Introductionmentioning

confidence: 99%

Crystal Structure of 2-pyridine-2-yl-3(pyridine-2-carboxylideneamino)quinazolin-4(3H)-one and its Ligating Diversity Towards Transition Metal(II) Ions

Gudasi

Vadavi

Shenoy

et al. 2006

Transition Met Chem

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The synthesis of a new ligand 2-pyridine-2-yl-3(pyridine-2-carboxylideneamino)-quinazolin-4(3H)-one (PPCAQ) is described together with its manganese(II), cobalt(II), nickel(II), copper(II), zinc(II) and cadmium(II) complexes. The single crystal X-ray diffraction studies of the ligand reveal the presence of two crystallographically independent molecules in asymmetric unit cell, which exhibit NÁ Á ÁN attractive interaction. The PPCAQ and its metal complexes were characterized by analytical, spectroscopic (i.r., n.m.r and u.v.-vis), magnetic moment, conductance and thermal studies. The i.r. spectral studies reveal the ligational diversity of the PPCAQ towards different metal ions as NNN donor in cobalt(II), copper(II), zinc(II) and cadmium(II) complexes and as ONN donor in manganese(II) and nickel(II) complexes. The antimicrobial activity of all the compounds was tested; copper(II), zinc(II) and cadmium(II) complexes show enhanced antibacterial activity compared to the free ligand.

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“…Looking into the wide variety of pharmacological activities of quinazolines [1][2][3][4][5], the varied behavior of the ring sulphur of thiophene in different ligand environment [10,11] and the role of metal ion in enhancement of pharmacological activity [11,12], we aim to search for a new 1,2-dihydroquinazoline (1) with R=2-thienyl, containing potential pharmacophores and coordinating sites towards transition metal ions. In continuation of our earlier studies on transition metal(II) complexes of 1,2-dihydro quinazolin-4(3H)-one [6], here we report the synthesis and characterization of the title ligand and its manganese(II), cobalt(II), nickel(II), copper(II), zinc(II) and cadmium(II) complexes by various spectral (u.v.-vis., i.r., 1D n.m.r., 2D hetcor and e.p.r.)…”

Section: Introductionmentioning

confidence: 99%

“…Many of them have been widely investigated for their therapeutic uses especially for anticancer [1], anti HIV [2], anti-inflammatory [3] and CNS depressant [4] activities. Particularly 1,2-dihydroquinazolin-4(3H)-one derivatives are known to be anticonvulsive and sedative agents [5].…”

Section: Introductionmentioning

confidence: 99%

Crystal Structure of 2-thiophene-2-yl-3(thiophene-2-carboxylideneamino)-1, 2-dihydroquinazolin-4(3H)-one and the Synthesis, Spectral and Thermal Studies of its Transition Metal(II) Complexes

Gudasi

Vadavi

Shenoy

et al. 2006

Transition Met Chem

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The synthesis of manganese(II), cobalt(II), nickel(II), copper(II), zinc(II) and cadmium(II) complexes of a new ligand 2-thiophene-2-yl-3(thiophene-2-carboxylidene-amino)-1,2-dihydroquinazolin-4(3H)-one (TTCADQ) is described. The ligand and metal complexes were characterized by elemental analysis, conductivity measurements, spectral (u.v.-vis., i.r., 1D n.m.r., 2D hetcor and e.p.r.) and thermal studies. The formation of 1,2-dihydroquinazolin-4(3H)-one rather than hydrazone, in the reaction of aromatic aldehyde and o-aminobenzoylhydrazide is proved by single crystal X-ray diffraction and 2D hetcor n.m.r. studies. On the basis of elemental analysis, u.v.-vis.spectroscopy and magnetic moment studies, six coordinate geometry for all the complexes was proposed. The i.r. spectral studies reveal the bidentate behaviour of the ligand.

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Synthesis and antiinflammatory and analgesic activities of quinolino[2,1-b]quinazoline derivatives

Cited by 5 publications

References 2 publications

Antimicrobial Study of Newly Synthesized Lanthanide(III) Complexes of 2‐[2‐hydroxy‐3‐methoxyphenyl]‐3‐[2‐hydroxy‐3‐methoxybenzylamino]‐1,2‐dihydroquinazolin‐4(3H)‐one

Antimicrobial Study of Newly Synthesized Lanthanide(III) Complexes of 2‐[2‐hydroxy‐3‐methoxyphenyl]‐3‐[2‐hydroxy‐3‐methoxybenzylamino]‐1,2‐dihydroquinazolin‐4(3H)‐one

Crystal Structure of 2-pyridine-2-yl-3(pyridine-2-carboxylideneamino)quinazolin-4(3H)-one and its Ligating Diversity Towards Transition Metal(II) Ions

Crystal Structure of 2-thiophene-2-yl-3(thiophene-2-carboxylideneamino)-1, 2-dihydroquinazolin-4(3H)-one and the Synthesis, Spectral and Thermal Studies of its Transition Metal(II) Complexes

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