Synthesis and antimicrobial activities of pyrido[2,3-d]pyrimidine, pyridotriazolopyrimidine, triazolopyrimidine, and pyrido[2,3-d:6,5d']dipyrimidine derivatives

Ecofriendly regioselective one-pot synthesis of chromeno[4,3-d][1,2,4]triazolo[4,3-a]pyrimidine derivatives

“…The identities of the products were concluded based on some spectroscopic data, although infrared carbonyl stretching data were inconclusive, there was a distinct pattern in the chemical shifts associated with the carbonyl resonance in the 13 C data. For example the two substituted products 5a and b showed carbonyl carbons resonances around 166-167 ppm, These values were consistent with some appropriate data shown by similar compounds obtained by other researchers in literature [10][11][12][18][19][20][21][22][23][24][25]; hence, based on these, one can conclude that structure 5 is the correct structure for the reaction product rather than its isomer 6. It is so clear to say that in structure 5 the carbonyl group is adjacent to sp 3hybrisized nitrogen atom while in the isomer 6 it is adjacent to more electronegative sp 2 -hybridized nitrogen atom in which the carbonyl carbon chemical shift should show more downfield values than those reported in literature.…”

Efficient synthesis and molecular docking of novel antibacterial pyrimidines and their related fused heterocyclic derivatives

“…[1][2][3][4][5][6][7][8][9][10][11][12][13] In addition, pyrido [2,3-d]pyrimidines exhibit antimicrobial, antifungal, and anti-inflammatory activities, [14][15][16] while thieno [2,3-d]pyrimidines exhibit antiproliferative and anti-inflammatory activities. Pyrimidines and their related fused heterocyclic derivatives possess antibacterial, antifungal, antiviral, anti-influenza, antioxidant, anti-inflammatory, antimalarial, antiproliferative, and antitumor activities.…”

An Efficient Solid Phase One Port Synthesis of Novel Triazolo[1,5-a]Pyrimidine Derivatives from 4-(4-Aminophenyl)Morpholin-3-One and Evaluation of their Antimicrobial Activity

“…Recently, 1,2,4-triazolo [1,5-a]pyrimidines have aroused increasing attention from the chemical and biological points of view due to their diverse pharmacological activities such as anti-inflammatory [5], antimalarial [6], antifungal effect [7], macrophage activation [8], antitumor potency [9][10][11][12], antimicrobial [13][14][15][16][20][21][22][23][24] and inhibition of KDR kinase [17]. They have proven to be promising anticancer [18] agents with dual mechanisms of tubulin polymerization promotion [9][10] as well as cyclin dependent kinases 2 inhibition [19].…”