Synthesis and antimicrobial activities of novel 1,5-diaryl pyrazoles

Interaction of 5-chloro-1-phenyl-1H-pyrazole-4-carboxamide and 5-chloro-N-formyl-1-phenyl-1H-pyrazole-4-carboxamide with hydrazine hydrate

“…Настоящая работа посвящена исследованию взаимодействия 5-хлорпиразолов 2 и 3 с гидра-зингидратом с целью получения новых произ-водных пиразола как потенциальных биоактив-ных веществ [2][3][4][5][6][7][8][9][10][11][12].…”

Synthesis and biological evaluation of novel 6, 7-dimethoxy-3-(4-pyridyl)-2,3,3a,4-tetrahydroindeno[1,2-c]pyrazol-2-yl-4-substituted phenylmethanone/ethanone derivatives

“…However, highly effective new anti-TB drugs have not been developed in the last 40 years. Literature survey of novel chemotherapeutic agents reveals that the substituted pyrazoline derivatives are proved to be active against many mycobacterial species [8][9][10][11][12][13][14] . Based on these literatures, the current work was designed to synthesize novel indane substituted pyrazoline derivatives.…”

Selectivity of amidrazones towards activated nitriles – synthesis of new pyrazoles and NMR investigation

“…Molecular modeling studies showed that pyrazole analogs interact with the cyclooxygenase-2 (COX-2) active site by classical hydrogen bonding, π-π interaction, and cation-π interaction which increases the residence of the ligand in the active site, consequently augmenting the anti-inflammatory activity of the compounds. 11 Anti-bacterial activity was also tested by Ragavan et al, 12 who have synthesized a group of 1,5-diaryl pyrazoles by altering the active part (amide linkage) and tested the products for anti-bacterial activity against E. coli (American Type Culture Collection [ATTC] -25922), S. aureus (ATTC-25923), Pseudomonas aeruginosa (ATTC-27853), and Klebsiella pneumonia. As anti-cancer agents, pyrazoles have potent anti-angiogenic activity, and inhibit the growth of human breast (MCF-7) and cervical (Hela) carcinoma cells in vitro.…”