Synthesis and Antimicrobial Activities of Some Novel 2,3-Substituted-1,3-Thiazolidin-4-ones Derived from 2-Amino-1,3-thiazole

Abstract

New 2,3-substituted-1,3-thiazolidin-4-one (6a-f) were prepared by cyclocondensation of 2-[6-(4-chlorobenzyloxy)-2-naphthyliden]-4-(4-substituted phenyl)-5-methyl-1,3-thiazole (5a-f) and mercaptoacetic acid in benzene. The synthesized compounds were characterized on the basis of elemental analysis, 1 H NMR, 13 C NMR and FT-IR. The prepared compounds have been screened in vitro against two Grampositive Staphylococcus aureus, Staphylococcus epidermidis, and two Gram-negative Escherichia coli, Pseudomonas aernuginosa for antibacterial activity and two fungal strains Candida albicans, Candida krusei for antifungal activity using ciprofloxacin, ampicillin and ketoconazole with minimal inhibitory concentration (MIC) value of 10 mcg/L in DMSO. Compounds 6a and 6d showed good antibacterial and antifungal activities compared to reference medications utilized within this study.

Schiff Bases Derived from 2-Hydroxynaphthalene-1-carbaldehyde and their Metal Complexes

“…For these reactions, H2O2 might have been all the more dynamic over air oxygen and sodium hypochlorite, also their ideal reaction states were investigated. able ligands prepared from the reaction of an amino compound with carbonyl groups [13,14]. The configuration of Schiff base, by and large, happens under corrosive or base catalysis or with warm.…”

“…3)formed from 2-hydroxy-1-naphthaldehyde and threonine. The stoichiometry of this Schiff bases was determined using FTIR, 1 H, 13 C NMR and UV spectroscopic strategies. X-ray beam diffraction technique was likewise used to get the single-precious crystal structure.…”