Synthesis and antimicrobial activities of a new class of 6-arylbenzimidazo[1,2-c]quinazolines

Rohini, Rondla; Shanker, Karuna; Reddy, P. Muralidhar; Vadde, Ramakrishna

doi:10.1590/s0103-50532010000100009

Cited by 36 publications

(24 citation statements)

References 30 publications

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“…Preliminary screening for all the metal salts, metal free ligands and complexes were performed at the fixed concentration of 1000 mg/ml. Based on the obtained values of the relative zone inhibition, [37][38][39][40][41][42][43] of the two ligands such as CEIMAP and CIMPAP and their complexes were found to be very effective (Table 4) than ligand free metal acetates and chlorides. Inhibition was recorded by measuring the diameter of the inhibition zone at the end of 24 h for bacteria.…”

Section: -27)mentioning

confidence: 99%

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Synthesis, Characterization and Biological Evaluation of Mononuclear Co(II), Ni(II), Cu(II) and Pd(II) Complexes with New N2O2 Schiff Base Ligands

Budige

Puchakayala

Kongara

et al. 2011

CHEMICAL & PHARMACEUTICAL BULLETIN

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Schiff bases have a variety of applications in biological, clinical, and pharmacological areas. The synthesis and application of Schiff bases and their coordination compounds have been highly considered in inorganic, organic and biological fields, since their structural properties similar to some of the biological systems.1-6) Additionally, tetradentate Schiff bases composed of N 2 O 2 donor atoms set have been recognized as a kind of important chelating ligands for designing medicinally and catalytically useful metal complexes. [7][8][9] The flexible coordination behavior of these types of chelating ligands could also be useful to generate interesting dimeric and polymeric structures as synthones for supramolecular chemistry. 10,11) Usually, the N, O donor heterodentate Schiff bases can be derived by condensing the aldehydes/ketones with various amines or amino acids. 12,13) N 2 O 2 Schiff base ligands derived from salicylald ehyde and diamine have been known. 14,15) Dialdehydes and diketones with amines and amino acids have also been utilized to obtain a variety of N 2 O 2 Schiff base ligands. 16)Amino acids plays an important role in many physiological activities of the human body and also helpful in understanding biological functions of macromolecules such as proteins. 17) In particular, tryptophan (Trp)/histidine (His) analogues as promising candidates for novel antimicrobial therapeutics. In the recent years, a series of synthetic peptide analogues based on Trp-His and His-Arg (antimicrobial peptides) structural frameworks have been prepared and found to be active against several Gram-positive and Gram-negative bacterial strains as well as against fungal strains.18) Furthermore, it is well known that the human body contains essential metaloelements which play important roles and interact with many biological molecules to fully understand the physiological functions by studying their chemistry coordination and behavior. 17,18) In the present studies we have introduced an azomethine (Schiff base) linkage to tryptophan/histidine, which may permit a variety in their coordination behaviour and complexation role.In previous studies, we have described the synthesis, catalytic and biological applications of Schiff bases and their metal complexes derived from o-phthalaldehyde (OPA) with various amines. [19][20][21][22][23][24][25][26][27] In this respect, we have also developed some useful macrocyclic Schiff bases and their metal complexes. Results from these studies have also shown that complexation of metals with Schiff base ligands serves to improve their antimicrobial activity. There are few other research groups also reported the importance of Schiff base chemistry of the combination of o-phthalaldehyde with amines.28,29) However, a careful literature survey reveals that Schiff bases from the combination of amino acids and o-phthalaldehyde and their coordination behavior towards the transition elements have yet not been studied. The combination of dialdehyde i.e. o-phthalaldehyde and aminoacids is expected to ...

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Section: -27)mentioning

confidence: 99%

“…The minimum inhibitory concentrations (MIC) of all these complexes were also verified by the liquid dilution method in which the effectiveness was observed at lower concentrations. [37][38][39][40][41][42][43] The comparison of the MICs (in mg/ml) of all complexes and standard drugs against tested strains are presented in Fig. 1.…”

Section: -27)mentioning

confidence: 99%

Synthesis, Characterization and Biological Evaluation of Mononuclear Co(II), Ni(II), Cu(II) and Pd(II) Complexes with New N2O2 Schiff Base Ligands

Budige

Puchakayala

Kongara

et al. 2011

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…Among the different functional moieties employed for this purpose, one commonly used is the nitrogen-containing heterocyclic compounds, which exhibit diverse biological and pharmacological activities. Compounds containing such an aza-heterocycle were described as trypanocidal agents, 1 glycogen phosphorylase inhibitors, 2 antitumor, 3 antiviral, 4 antimicrobial agents, 5 antimycobacterial, 6 among others. 7 In particular, two widely known classes have been subject of investigation by our research group, namely the benzoheterocyclic compounds and the triazoles.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of a new class of triazole-linked benzoheterocycles via 1,3-dipolar cycloaddition

Barbosa¹,

Oliveira²

2011

J. Braz. Chem. Soc.

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Uma nova série de derivados 1,2,3,-triazólicos foi sintetizada a partir de ftalimidas e alcinos terminais na presença de quantidade catalítica de CuI. O presente protocolo forneceu 1,2,3-triazóis em moderados a bons rendimentos (44-89%).A new series of 1,2,3-triazole derivatives have been synthesized from phthalimides and terminal alkynes in the presence of a catalytic amount of CuI. The present protocol affords 1,2,3-triazoles in moderate to good yields (44-89%).

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“…ESI-MS spectra of all the compounds showed a single peak suggesting the molecular formulae. In addition, the FAB mass spectrum of compound (11) [34][35][36] Ampicillin and Ketoconazole were used as standard drugs for bacteria and fungi respectively. Preliminary screening of quinazolines and standard drugs were performed at fixed concentrations of 1000 µg mL…”

Section: Chemistrymentioning

confidence: 99%

“…[34][35][36] Stock solutions of tested compounds with 2.5, 5, 10, 15, 20, 25, 30, 35, 40, 45 and 50 µg mL -1 concentrations were prepared with appropriate solvent. The solutions of standard drugs, Ampicillin and Ketoconazole were prepared in the same concentrations.…”

Section: Determination Of Minimum Inhibitory Concentration (Mic)mentioning

confidence: 99%

Synthesis of some new mono, bis-indolo[1, 2-c]quinazolines: evaluation of their antimicrobial studies

Rohini¹,

Reddy²,

Shanker³

et al. 2010

J. Braz. Chem. Soc.

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Synthesis and antimicrobial activities of a new class of 6-arylbenzimidazo[1,2-c]quinazolines

Cited by 36 publications

References 30 publications

Synthesis, Characterization and Biological Evaluation of Mononuclear Co(II), Ni(II), Cu(II) and Pd(II) Complexes with New N2O2 Schiff Base Ligands

Synthesis, Characterization and Biological Evaluation of Mononuclear Co(II), Ni(II), Cu(II) and Pd(II) Complexes with New N2O2 Schiff Base Ligands

Synthesis of a new class of triazole-linked benzoheterocycles via 1,3-dipolar cycloaddition

Synthesis of some new mono, bis-indolo[1, 2-c]quinazolines: evaluation of their antimicrobial studies

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