Synthesis and Antimicrobial Activities of Chalcones and Indole Derived from Acetyl Pyridines

Abstract

Chalcones due to its diverse biological and pharmacological activities have generated extensive scientific studies throughout the world. Chalcones having substitution on two aryl rings exhibit anticancer, antioxidant, anti-inflammatory, antimicrobial, antiulcer, antimalaria and many other activities [1-9]. Chalcones and their derivatives have also been seen to find applications in large varieties of diverse areas such as artificial sweeteners [10], scintillator [11], stabilizer against heat, visible light, ultraviolet light and aging [12,13]. In agriculture, chalcones are used to destroy phytopathogenic organisms [14]. Similarly in industry chalcones are also used in anti-sunburn oil [15]. Indole nucleus is a biologically accepted pharmacophore in medicinal compounds. Compounds bearing indole nucleus exhibit wide spectrum of biological activities such as antifungal, antimicrobial, antiviral, antitubercular, anticancer etc. [16,17]. In the present study, it was thus been decided to synthesize and characterize chalcones and indole bearing nitrogen containing heterocyclic ring such as pyridine ring with substitutions selected from-F,-NO2,-NH2 and to screen the antibacterial and antifungal activity of the synthesized compounds.

Synthesis and Evaluation of Antimicrobial Activity of Pyrimidine Derivatives

“…In vitro antibacterial activity of synthesized pyrimidine derivatives (in DMSO solution at the concentration of 5 mg/mL) was studied as reported elsewhere [27] against bacterial strains by the agar well diffusion method [28]. Mueller-Hinton agar no.…”

“…Synthesized pyrimidine derivatives were screened for their antifungal activity as reported elsewhere [27] using agar well diffusion method [29]. The fungal spore was prepared by sterile PBS.…”