Synthesis and antimicrobial activity of some 2- Piperidinomethylamino-4-(7-H/substituted coumarin-3-yl)- 6-chlorosubstitutedphenyl pyrimidines

Imran, Mohd; Alam, Ozair; Abida, Abida

doi:10.4314/tjpr.v15i9.21

Cited by 6 publications

(8 citation statements)

References 10 publications

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“…But MCPM3DMPO and TSPM3DMPO showed complete inhibition of test isolate at 100µg/mL concentration against Proteus species. These results are supported by one another study of Imran et al 49 . Desai et al 50 .…”

Section: Discussionsupporting

confidence: 84%

Study on Multi Drug Resistant Opportunistic Pathogens Obtained from Clinical Settings of Tamil Nadu for Developing Novel Alternative Therapeutics

Venkatasubramani¹,

Viswanathan²

2019

J Pure Appl Microbiol

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Opportunistic pathogens prevail in the hospital environment, and utensils are the root cause of severe nosocomial infection. These pathogens exhibit high antibiotic resistance due to constant exposure to drug therapy. This study focuses on screening antibiotic-resistant opportunistic pathogen and effectiveness of piperidine compounds against the opportunistic pathogens. Standard microbiological laboratory protocols were used and followed, and about 238 samples were processed and screened. Among them, 47 reported positive for the presence of pathogens like Staphylococcus species, Salmonella species, Pseudomonas species, Proteus species, E. coli and Klebsiella species. In antibiotic resistance screening, the maximum resistance percentage was recorded against Ampicillin and Chloramphenicol (100%). The least percentage of resistance was noticed against Carbenicillin (41%). Piperidine compounds showed promising susceptibility towards test isolates. The MIC of the compounds against E. coli and Staphylococcus sp. was found to be higher when compared to Klebsiella sp.

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Section: Discussionsupporting

confidence: 84%

Study on Multi Drug Resistant Opportunistic Pathogens Obtained from Clinical Settings of Tamil Nadu for Developing Novel Alternative Therapeutics

Venkatasubramani¹,

Viswanathan²

2019

J Pure Appl Microbiol

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“…In the study conducted by Imran et al 35 the MIC of test compounds ranged between 25-50µg/mL against E. coli, P. aeruginosa, K. pneumonia, S. aureus, and P. vulgaris. But in the case of the present study, the MIC range varies between 6.25 to 200µg/mL.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Study of Multidrug Resistant and Efficiency of Piperidine Compounds against Hospital Acquired Opportunistic Pathogens in Tamil Nadu, India

Venkatasubramani¹,

Viswanathan²

2020

J. Pure Appl. Microbiol.

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The pathogens attained through nosocomial infection exhibit a higher degree of antibiotic resistance due to constant exposure to drug therapy. There is a need to develop alternate therapeutics for treating these resistant pathogens. Objective: The objective of this study is to isolate pathogens from hospital-acquired infection to determine its epidemiology and multidrug resistance. In this study, urine and swab samples (354) were obtained from hospitalized patients with no prior infection history. For screening antibiotic resistance among the isolates, 15 antibiotics were used in this study, and also various piperidine compounds were used to evaluate the minimum inhibitory concentration against the isolates. Among them, 160 reported positive for the presence of Staphylococcus species (37), Salmonella species (23), Pseudomonas species (27), Proteus species (21), E. coli (34) and Klebsiella species (18). Mostly, all the pathogens obtained from clinical cases show high antibiotic resistance. The highest percentage of resistance was recorded against amoxicillin and penicillin (98%). The least rate of resistance was noticed against gentamycin (42%). Like antibiotics, the test compounds exhibited better minimum inhibitory concentration (MIC) against the test isolates. The MIC of the compounds against Staphylococcus species and E. coli was discovered to be higher when compared to Klebsiella species and Salmonella species. The piperidine compounds that were used as alternatives showed promising susceptibility towards pathogens.

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“…[108] compounds in reasonable-to-good yields which were shown in Table 2. [113,114] According to the proposed mechanism, [147] addition of guanidine to chalcone (4) forms intermediate A. Intermediate B is formed by the intramolecular nucleophilic addition of the amine to the carbonyl group, which is followed by the elimination of water to give compound 49 (Scheme 10).…”

Section: Mechanisms For Cycloaddition Reactionmentioning

confidence: 99%

Coumarin‐Chalcones Generated from 3‐Acetylcoumarin as a Promising Agent: Synthesis and Pharmacological Properties

et al. 2022

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antituberculosis; enzyme-inhibition; antioxidant; anti-inflammatory etc. After introducing the synthesis of 3-acetylcoumarin, the review proceeds with a comprehensive presentation of the synthesis of coumarin-chalcones under various conditions. Last, the reactions of prepared coumarin-chalcones through different mechanisms and the outcomes achieved through such reactions are discussed. It is envisaged that this review will prompt researchers to expand on the knowledge gained in this field the last twenty years.

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Synthesis and antimicrobial activity of some 2- Piperidinomethylamino-4-(7-H/substituted coumarin-3-yl)- 6-chlorosubstitutedphenyl pyrimidines

Abstract: Purpose: To prepare and evaluate some 2-piperidinomethylamino-4-(7-H/substitutedcoumarin-3-yl)-6-chlorosubstitutedphenyl pyrimidines as antimicrobial agents. Methods: Some 2-piperidinomethylamino-4-(7-H/substitutedcoumarin-3-yl)-

Cited by 6 publications

References 10 publications

Study on Multi Drug Resistant Opportunistic Pathogens Obtained from Clinical Settings of Tamil Nadu for Developing Novel Alternative Therapeutics

Study on Multi Drug Resistant Opportunistic Pathogens Obtained from Clinical Settings of Tamil Nadu for Developing Novel Alternative Therapeutics

Epidemiological Study of Multidrug Resistant and Efficiency of Piperidine Compounds against Hospital Acquired Opportunistic Pathogens in Tamil Nadu, India

Coumarin‐Chalcones Generated from 3‐Acetylcoumarin as a Promising Agent: Synthesis and Pharmacological Properties

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