Synthesis and Antimicrobial Activity of 5‐(R¹‐Benzyl)‐2‐(R‐benzylidenehydrazono)‐3‐ (2‐furylmethyl)thiazolidin‐4‐ones.

Abstract

Thiazole derivatives R 0260Synthesis and Antimicrobial Activity of 5-(R 1 -Benzyl)-2-(R-benzylidenehydrazono)-3-(2-furylmethyl)thiazolidin-4-ones. -Among the title thiazolidinones prepared, only derivatives (IIIa) and (IIIb) containing a tolylmethyl residue at the thiazolidinone ring possess antimicrobial activity. -(TSYALKOVSKII, V. M.; KUTSYK, R. V.; MATIYCHUK, V. S.; OBUSHAK, M. D.; KLYUFINSKA, T. I.; Khim.-Farm. Zh. 39 (2005) 5, 20-22; L'viv Natl. Univ., L'viv 79602, Ukraine; Russ., Abstr. Eng.) -Mischke 41-132

Synthesis and antimicrobial activity of 4-(5-ARYL-2-FUROYL)morpholines and 4-[(5-ARYL-2-FURYL)carbonothioyl] morpholines

“…The development of methods of combinatorial synthesis of heterocyclic compounds and their biological evaluation are important points in organic and medical chemistry. In our previous work we have developed methods of synthesis of furan (Obushak et al 2008;Gorak et al 2009), pyrazole (Matiichuk et al 2008), thiazole (Tsyalkovsky et al 2005;Zimenkovskii et al 2006;Ostapiuk et al 2012;Chaban et al 2019a) and triazole (Pokhodylo et al 2009a) derivatives based on using of diazonium salt as starting reagents. Some condensed molecules were also prepared (Pokhodylo et al 2009b;Zubkov et al 2010;Klenina et al 2013Klenina et al , 2017Chaban et al 2014Chaban et al , 2016Chaban et al , 2017Chaban et al , 2018Chaban et al , 2019bZelisko et al 2015).…”