Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid

Siebert, Agnieszka; Wysocka, Magdalena; Krawczyk, Beata; Cholewiński, Grzegorz; Rachoń, Janusz

doi:10.1016/j.ejmech.2017.11.094

Cited by 25 publications

(14 citation statements)

References 42 publications

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“…The mixture was stirred for 2 h in ice bath, and HO‐PCL‐OH of M n = 4.5 × 10 4 (4 g, 8.9 × 10 −5 mol) dissolved in tetrahydrofuran (25 mL) was added. The reaction continued for 24 h at room temperature . The products were precipitated and washed with distilled water for five times and freeze‐dried to give the end‐group heparinized PCL (PCL‐O‐Hep).…”

Section: Methodsmentioning

confidence: 99%

Preparation of Small‐Diameter Tissue‐Engineered Vascular Grafts Electrospun from Heparin End‐Capped PCL and Evaluation in a Rabbit Carotid Artery Replacement Model

Jin

Geng

Jia³

et al. 2019

Macromolecular Bioscience

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Aiming to construct small diameter (ID <6 mm) off‐the‐shelf tissue‐engineered vascular grafts, the end‐group heparinizd poly(ε‐caprolactone) (PCL) is synthesized by a three‐step process and then electrospun into an inner layer of double‐layer vascular scaffolds (DLVSs) showing a hierarchical double distribution of nano‐ and microfibers. Afterward, PCL without the end‐group heparinization is electrospun into an outer layer. A steady release of grafted heparin and the existence of a glycocalyx structure give the grafts anticoagulation activity and the conjugation of heparin also improves hydrophilicity and accelerates degradation of the scaffolds. The DLVSs are evaluated in six rabbits via a carotid artery interpositional model for a period of three months. All the grafts are patent until explantation, and meanwhile smooth endothelialization and fine revascularization are observed in the grafts. The composition of the outer layer of scaffolds exhibits a significant effect on the aneurysm dilation after implantation. Only one aneurysm dilation is detected at two months and no calcification is formed in the follow‐up term. How to prevent aneurysms remains a challenging topic.

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Section: Methodsmentioning

confidence: 99%

Preparation of Small‐Diameter Tissue‐Engineered Vascular Grafts Electrospun from Heparin End‐Capped PCL and Evaluation in a Rabbit Carotid Artery Replacement Model

Jin

Geng

Jia³

et al. 2019

Macromolecular Bioscience

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“…Compounds 125 (SI = 2871.4) , 126 (SI = 33,787.9), and 127 (SI = 7166.7) exhibited higher potency than MPA in vitro . In addition, Siebert et al ( 2018 ) obtained novel amino acid MPA derivatives as potential antibacterial agents. Peptide derivatives proved to be the most versatile, and their strains were relative to most MIC values lower than MPA.…”

Section: Application Of Amino Acids In the Structural Modification Of Natural Productsmentioning

confidence: 99%

Application of Amino Acids in the Structural Modification of Natural Products: A Review

Deng

et al. 2021

Front. Chem.

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Natural products and their derivatives are important sources for drug discovery; however, they usually have poor solubility and low activity and require structural modification. Amino acids are highly soluble in water and have a wide range of activities. The introduction of amino acids into natural products is expected to improve the performance of these products and minimize their adverse effects. Therefore, this review summarizes the application of amino acids in the structural modification of natural products and provides a theoretical basis for the structural modification of natural products in the future. The articles were divided into six types based on the backbone structures of the natural products, and the related applications of amino acids in the structural modification of natural products were discussed in detail.

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“…Similarly, 37.2% of the mycotoxin content in 89 blue‐veined cheese contained quantifiable amounts of mycophenolic acid (Fontaine et al., 2015). Mycophenolic acid was identified as a potent antibiotic against Bacillus anthracis , which was later reported to have antiviral, antifungal, antitumor, and immunosuppressant properties (Siebert, Wysocka, Krawczyk, Cholewiński, & Rachoń, 2018). Selection and use of beneficial fungal strains that enhance the technological and functional properties of cheese and inhibit the growth of toxin‐producing molds can decrease incidences of cheese spoilage while increasing the bioactive property of the cheese product.…”

Section: Microorganisms Associated With Cheese Productionmentioning

confidence: 99%

Biotechnological approaches for the production of designer cheese with improved functionality

Chourasia¹,

Abedin²,

Phukon³

et al. 2020

Comp Rev Food Sci Food Safe

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Cheese is a product of ancient biotechnological practices, which has been revolutionized as a functional food product in many parts of the world. Bioactive compounds, such as peptides, polysaccharides, and fatty acids, have been identified in traditional cheese products, which demonstrate functional properties such as antihypertensive, antioxidant, immunomodulation, antidiabetic, and anticancer activities. Besides, cheese‐making probiotic lactic acid bacteria (LAB) exert a positive impact on gut health, aiding in digestion, and improved nutrient absorption. Advancement in biotechnological research revealed the potential of metabolite production with prebiotics and bioactive functions in several strains of LAB, yeast, and filamentous fungi. The application of specific biocatalyst producing microbial strains enhances nutraceutical value, resulting in designer cheese products with multifarious health beneficial effects. This review summarizes the biotechnological approaches applied in designing cheese products with improved functional properties.

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Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid

Cited by 25 publications

References 42 publications

Preparation of Small‐Diameter Tissue‐Engineered Vascular Grafts Electrospun from Heparin End‐Capped PCL and Evaluation in a Rabbit Carotid Artery Replacement Model

Preparation of Small‐Diameter Tissue‐Engineered Vascular Grafts Electrospun from Heparin End‐Capped PCL and Evaluation in a Rabbit Carotid Artery Replacement Model

Application of Amino Acids in the Structural Modification of Natural Products: A Review

Biotechnological approaches for the production of designer cheese with improved functionality

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