Synthesis and Antimicrobial Activity of Functional Derivatives of thiazolo[ 2,3-c][1,2,4]triazoles

Abstract

Background: Condensed triazoles are a well-known class of heterocyclic compounds due to a wide range of biological activity. The study is dedicated to the evaluation of the antimicrobial potential of new functional derivatives of thiazolo[2,3-c][1,2,4]triazoles. Methods: Effective, easy-to-implement and low-cost routes to the production of title compounds via electrophilic intramolecular heterocyclization are reported. Bactericidal and fungicidal activities against Gram-positive and Gram-negative bacteria, and fungus were studied. The influence of functional groups on the biological activity of tested thiazolo[2,3-c][1,2,4]triazoles is discussed. Results: Microbiological evaluation shows that 6-[(trichlorotellanyl)methyl]-[1,3]thiazolo[2,3-c][1,2,4]triazol-3-amine hydrogen chloride 2a and 3-(2-hydroxyphenyl)-6-[(trichloro-λ4-tellanyl)methyl]-5,6-dihydro-[1,3]thiazolo[2,3-c][1,2,4]triazole 2g have a high bactericidal activity and Cu (I) salts of 3-(2-hydroxyphenyl)-6-iodomethyl/6-methylidene-5,6-dihydro-[1,3]thiazolo-[2,3-c][1,2,4]triazoles 5a,c have a high fungicidal activity. Conclusion: it must be concluded that these products or their derivatives may be of practical benefit as bactericidal and fungicidal agents.

Synthesis, Crystal Structure, Spectral Characterization and Antifungal Activity of Novel Phenolic Acid Triazole Derivatives

“…For example, Li and Wu, who combined triazoles with pyrimidine, both obtained compounds with good antibacterial activity [25]. Slivka et al synthesized several compounds with triazole, thiazole and phenol substituents and their copper complexes, and the synthesized compounds had good fungicidal activity [26]. We found that most triazole pesticides are derivatives in which the nitrogen atom of the triazole ring is substituted by alkyl or aralkyl.…”