Synthesis and Antimicrobial Activity of Some 3‐Alkyl‐4‐(arylmethyleneamino)‐4,5‐dihydro‐1H‐1,2,4‐triazol‐5‐ones.

Abstract

Pyrazole derivatives R 0180Synthesis and Antimicrobial Activity of Some 3-Alkyl-4-(arylmethyleneamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones. -The new acetate (III) and hydrazine derivatives (IV) of the title triazolone system are synthesized. They show significant antibacterial, antifungal and antipseudomonal activities. -(KAHVECI*, B.; BEKIRCAN, O.; KARAOGLU, S. A.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 44 (2005) 12, 2614-2617; Dep. Chem., Karadeniz Tech. Univ., TR-53100 Rize, Turk.; Eng.) -A. Forchert 15-111

Synthesis of New Bis-1,2,4-Triazole Derivatives

“…For example, fluconazole is used as an antimicrobial drug [17], while vorozole, letrozole and anastrozole are non-steroidal drugs used for the threatment of cancer [18] and loreclezole is used as an anticonvulsant [19]. Furthermore, in recent years some Schiff base derivatives of 1,2,4-triazoles and their reduced derivatives have been also found to possess pharmacological activities [20][21][22][23][24][25][26]. These biological data prompted us to synthesize some new bis-1,2,4-triazole derivatives, and in the present study, a novel series of bis-Schiff base derivatives resulting from the reaction of 4-amino-3-aryl-5-phenyl-4H-1,2,4-triazoles 3 with bis-aldehydes 1 and their corresponding reduced derivatives were synthesized and characterized by IR, 1 H-NMR, 13 C-NMR and mass spectral data.…”

Synthesis, Identification and Evaluation the Biological Activity for Some New Heterocyclic Compounds Derived from Schiff Bases

“…FTIR spectrum showed disappearance of absorption band for NH 2 group and appearance of the absorption band at (1668-1647)cm -1 to (C=N) [19] and show other different absorption bands for the substituted groups that are listed in Table (1). 1 HNMR spectrum for ( ) w υ 7.30-8.42 ppm; υ8.65 ppm (s, 1H, -N=CH-); υ 9.16 ppm (s, 1H, -CS-NH-Ph); (m, 13H, Ar-H) and υ10.30 ppm (s, 1H, -CO-NH-CS-) [20 figure (1). 13 CNMR spectrum for this compound show signals listed in Table (7) and figure (2). Schiff bases were cyclized by using four different steps with different reagents.…”

“…These compounds can be formed by react the primary amines with aldehydes or ketones in presence either acid, base or heat as a catalyst of the reaction [1]. Great deals of research have reported that Schiff bases which are derived from the heterocyclic compounds are antimicrobial [2], antiproliferative [3], anticonvulsant [4], cytotoxic [5] and anticancer [6]. Like the other organic compounds, schiff bases which consist of four, five and seven membered rings have biological activities based on its spectrum therefore many of industrial and medical applications like pigments and dyes take place in these fields [7][8][9].…”

Crystal structure, spectroscopic and redox behaviour of novel imidazolidine ligand

“…Moreover, Schiff bases derived from various heterocycles have been reported to possess cytotoxic [2], anticonvulsant [3], antiproliferative [4], antimicrobial [5], anticancer [6], and antifungal activities [7]. Mannich bases have gained importance due to their application in pharmaceutical chemistry.…”