Synthesis and antimicrobial activity of certain novel quinoxalines

Abstract

In this study, certain 3-methyl-2-[4-(substituted amino carbonyl)anilino] quinoxalines, (2a-d) and (3a-d), were synthesized from the new key compound 2-[4-(ethoxycarbonyl)anilino]-3-methyl quinoxaline (1). In addition, a series of 2-[4-(arylidene hydrazinocarbonyl)anilino]-3-methyl quinoxalines (5a-e), as well as their cyclized oxadiazolinyl derivatives (6a-e), and a series of 2-[4-N2-acylhydrazinocarbonyl) anilino]-3-methyl quinoxalines (7a-d), as well as their cyclized oxadiazoiyl derivatives (8a-d) were also prepared. Some of these derivatives were evaluated for antimicrobial activity in vitro. It was found that all the selected compounds exhibit antimicrobial activity and that compound 5b had a broad spectrum of activity.

Conventional and Microwave Assisted Synthesis of Quinoxaline Carboxamide Derivatives

“…The versatility of the quinoxalines, in addition to its chemical simplicity and accessibility, makes them the most promising sources of bioactive heterocycles.The quinoxaline skeleton is used as an intermediate in designing novel quinoxaline derivatives with potential as anticancer [1][2][3], antiviral [4], antimicrobial (or antifungal) [3], anticandida [5,6], antithrombotic [7], anxiolytic agents and other activities. Moreover, quinoxaline based drugs have shown to be photochemical DNA cleaving agents making them highly promising scaffolds for anticancer therapeutics.…”

Synthesis of Thiophenyl Thiazole Based Novel Quinoxaline Derivatives

“…These are important components of several pharmacologically active compounds [2][3][4][5][6][7][8] and exhibit special and wider ranges of functions in biologically active compounds [9], electroluminescent materials [10], dyes [11] and anion sensors [12]. Although rarely describe in nature, synthetic quinoxaline derivatives showed variety of pharmaceutical activities encompassed major types of drug target families and effective in many clinical applications such as anti tumor agents [13], kinase inhibitors [14], HIV drugs [15], antibiotics [16], ion channel regulators [17] and anti protozoal agents [18].…”

Synthesis and anticonvulsant activity of Schiff’s bases of 3-{[2-({(E)-[(substituted) phenyl] methylidene} amino) ethyl] amino} quinoxalin-2(1H)-one

“…They have been reported for their applications in dyes and have also been used as building blocks for the synthesis of organic semiconductors. Quinoxalines are very important compounds due to their wide spectrum of biological activities behaving as anti-cancer (Moarbess and Masquefa, 2008) antibacterial (Refaat and Moneer, 2004) anti-inflamatory (Hashem and Gouda, 2010), anti-histaminic agent (Sridevi and Balaji, 2010) anti-trypanosomal activity (Urquiola, 2006) antiherps (Harmenberg and Wahren, 1988) antiplasmodial activity (Zarranz et al2006) Ca uptake/release inhibitor (Xia et al, 2005) inhibit vascular smooth muscle cell proliferation (Chung, 2005), antimalarial (Vicente et al, 2008). These are useful as intermediates for many target molecules in organic synthesis and also as synthons.…”