Synthesis and Antimicrobial Activity of Some New Flavonyl Oxime Ether Derivatives

Tunçbìlek, Meral; Bozdağ, Oya; Ayhan-Kılcıgi̇l, Gülgün; Altanlar, Nurten; Büyükbingöl, Erdem; Ertan, Rahmiye

doi:10.1055/s-0031-1300514

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…The relationship between flavonoid structure and antibacterial activity has also been examined by several researchers (Wang et al . 1992; Tuncbilek et al . 1999; Bozdag‐Dundar et al .…”

Section: Resultsmentioning

confidence: 99%

“…Some examples mentioned by Cushnie and Lamb (2005), which have been isolated, identified and whose antibacterial activity was demonstrated, are apigenin, galangin, pinocembrin, naringin, naringenin, luteolin and luteolin 7-glucoside, quercetin, 3-O-methylquercetin and various quercetin glycosides, kaempferol and its derivatives. The relationship between flavonoid structure and antibacterial activity has also been examined by several researchers (Wang et al 1992;Tuncbilek et al 1999;Bozdag-Dundar et al 2003;Stapleton et al 2004). Wang et al (1992) complexed 5-hydroxy-7,4-dimethoxyflavone with Cu(II), Ni(II), Co(II), Zn(II), Fe(III), Cr(III), Cd(II) and Mn(II), and showed that this process increases antibacterial activity.…”

Section: Metals Phenolics and Antimicrobial Action In Plantsmentioning

confidence: 99%

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Correlation Among Metallic Ions, Phenolic Compounds and Antimicrobial Action in Medicinal Plants Extracts

Ducat¹,

Torres²,

Santa³

et al. 2011

Journal of Food Quality

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The extracts of three different medicinal plants –Calendula officinalis L., Maytenus ilicifolia Martius ex Reissek and Cymbopogon citratus (DC) Stapf – obtained with 70% and 95% v/v ethanol had their antimicrobial activity tested against five pathogenic microorganisms. A quantitative analysis of total phenols, flavonoids and mineral species was performed on the extracts using UV‐vis spectroscopy and atomic absorption spectroscopy. Klebsiella pneumoniae showed the greatest sensibility to the extracts tested. The mineral content of the medicinal herbs varied according to the type of plant (Cu = not detected to 10.90; Zn = 0.85 to 10.04; Na = 24.94 to 153.62; Al = 90.04 to 420.39; Mg = 9.62 to 1,129.15; Ca = 7.15 to 167.27 and K = 913.85 to 9,578.94 µg/g); however, the concentration of heavy elements (Pb, Cd and Cr) was null in the extracts. The concentrations of flavonoids ranged from 13.55 to 41.54 mg/g and 92.35 to 518.28 mg/g for phenolic acids. PRACTICAL APPLICATIONS The use of plants with pharmacological activities has increased significantly because of their functional properties in the diet for the promotion of human health and antimicrobial effects. Moreover, medicinal herbs play an important role in public health, especially in developing countries. In Brazil, the use of plant extracts in the treatment of certain diseases is very common. This habit can be explained, at least in part, by the belief that herbs with therapeutic effects do not have toxic effects on the organism. In this paper, ethanolic extracts of three medicinal plants, widely cultivated and used by the population of Brazil and worldwide, had their levels of metals ions and total phenolic compounds determined. Antimicrobial activity of the extracts was evaluated against foodborne pathogens or food spoilage organisms or clinically isolates microorganisms.

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“…The relationship between flavonoid structure and antibacterial activity has also been examined by several researchers (Wang et al . 1992; Tuncbilek et al . 1999; Bozdag‐Dundar et al .…”

Section: Resultsmentioning

confidence: 99%

Section: Metals Phenolics and Antimicrobial Action In Plantsmentioning

confidence: 99%

Correlation Among Metallic Ions, Phenolic Compounds and Antimicrobial Action in Medicinal Plants Extracts

Ducat¹,

Torres²,

Santa³

et al. 2011

Journal of Food Quality

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Antimicrobial and Antiviral Screening of Novel Indole Carboxamide and Propanamide Derivatives

Ölgen

Altanlar

Karataylı

et al. 2008

Zeitschrift Für Naturforschung C

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A few series of indole derivatives were screened for antimicrobial, antifungal and anti-HBV activities. The compounds were tested for their in vitro antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and for their antifungal activity against Candida albicans using a disc diffusion method, which measures the diameter of the inhibition zone around a paper disc soaked in a solution of the test compounds. The antimicrobial activity results showed that all compounds are as a active as the standard compound ampicillin against Staphylococcus aureus. It was also found that indole carboxamide derivatives, substituted at 3-position with several benzyl groups, showed better inhibition of Bacillus subtilis than their congeners substituted at 2-position. Activity patterns of the compounds against Escherichia coli and Staphylococcus aureus were found slightly different by the same method. In this case, there was no correlation between structure and activity of the compounds. The antifungal activity of carboxamide derivatives was found higher compared to that of the propanamide derivatives. The minimum inhibitory concentration (MIC) values of some indole derivatives were also determined by the tube dilution technique. The MIC values of the compounds were found nearly 20-to 100-fold smaller compared to the standard compounds ciprofloxacin and ampicillin (1.56Ð3.13 μg/ml and 1.56Ð12.5 μg/ml, respectively) against Staphylococcus aureus, Bacillus subtilis and Escherichia coli. The MIC values of the tested compounds showed that these are better inhibitors for Candida albicans. Indole derivatives were screened by the anti-HBV susceptibility test. No compound showed good inhibition against the HBV virus.

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Chemical modifications and transformations of 3-azahetarylchroman-4-ones

2016

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Articles reporting on the chemical modifications and transformations of 3-azahetarylchroman-4-ones are rewieved. The following 3-azahetarylchroman-4-ones’ transformation - reduction of 3-azahetarylchromon-4-ones to the corresponding 3-azahetarylchromanols, -chromenes, and -3,4-dihydrochromenes, alkylation of 3-azahetarylchromanols, reconversion into 3-azahetarylchromones, formation of 3-hetarylchroman-4-one oximes and corresponding oxime ethers, recyclization into 3-aryl-4-hetarylpyrazolines are described. The biological activity of 3-azahetarylchroman-4-one modification or transformation products are also adduced.

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Synthesis and Antimicrobial Activity of Some New Flavonyl Oxime Ether Derivatives

Cited by 3 publications

References 6 publications

Correlation Among Metallic Ions, Phenolic Compounds and Antimicrobial Action in Medicinal Plants Extracts

Correlation Among Metallic Ions, Phenolic Compounds and Antimicrobial Action in Medicinal Plants Extracts

Antimicrobial and Antiviral Screening of Novel Indole Carboxamide and Propanamide Derivatives

Chemical modifications and transformations of 3-azahetarylchroman-4-ones

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