Synthesis and antimicrobial activity of 4-phenyl/cyclohexyl-5-(1-phenoxyethyl)-3-[N-(2-thiazolyl)acetamido]thio-4H-1,2,4-triazole derivatives

Potentiometric Determination of Pharmaceutically Important Nimesulide in Non-Aqueous Medium

“…Many literatures have shown that Mannich bases possess potent biological activities such as antibacterial, antifungal, anti-inflammatory, antimalarial and pesticide properties [8][9][10][11] . Few Mannich bases derived from 1,2,4-triazoles carrying N-methylpiperzine substituent were biologically active 12,13 . 4,5-Substituted products containing 1,2,4-triazole in their molecules seem to be suitable candidates for further chemical modifications and might be of interest as pharmacologically active compounds and ligands useful in coordination chemistry 14 .…”

Synthesis and Antibacterial Activities of NovelS-β-D-Glucosides of 1,2,4-Triazole

“…1,2,4-三唑衍生物作为杂环化合物 的一类重要物质, 在诸多领域显示出优异的生物活性, 如抗菌 [2,3,4,5] 、抗癌 [6,7,8] 、抗病毒 [9] 、抗消炎 [10] 、抗惊 厥 [11] 等. 1,2,4-三唑衍生物对 HIV-RT、羊毛甾醇 14α-去 甲基化酶等病原体的靶标具有较强的亲合性和特异 性 [12] , 卤代邻羟基二苯醚是靶点烯脂酰--ACP 还原 酶(FabI)的指向性的酶抑制剂 [13] , 据此, 本课题组设计 合成了一批具有良好生物活性的邻羟苯基三唑类化合 物 [14] , 证实了卤素取代能有效提高目标化合物的抗菌 对白色念珠菌、金黄色葡萄球菌、大肠杆菌具有很好的 抑菌效果 [15] .…”

Synthesis of Novel Halobenzyloxy and Alkoxy 1,2,4-Triazoles and Evaluation for Their Antifungal and Antibacterial Activities

“…[19][20][21][22][23][24][25] The alterations in chemical structure of substituted 1,2,4-triazoles could affect their interactions with cells and tissues, thereby exhibiting different biological effects. Furthermore, much research manifested that incorporation of fluorine or chlorine moiety into an organic molecule could efficiently improve the pharmacological properties, [26][27][28][29] which resulted in increasing lipid solubility, accordingly enhancing the rate of absorption and transport of drugs in vivo.…”