Synthesis and Antimicrobial Activity of some New Heterocycles Based on 3-Methyl-1-Phenyl-5-Benzene Sulfonamido Pyrazole

Pyridazine and its related compounds. Part 35 [1]: Synthesis, characterization and antimicrobial activity of some novel pyridazine and triazolopyridazine containing sulfonamides

“…Moreover, for SAR study, we aimed to synthesize a new series of sulfonamides 3a-i and 6a-i to investigate the effect of attaching triazole ring (of the known pharmacological activity) to pyridazine nucleus upon the required activity as antimicrobial agents. The synthesized compounds were characterized by various spectroscopic methods such as IR, 1 H NMR, 13 C NMR and MS, elemental and spectral analyses of all prepared compounds described are consistent with the assigned structures.…”

“…13 To a solution of 3-mercapto derivative 4 (2.6 mmol) in acetic acid (19 mL) and water (1 mL), chlorine gas was bubbled at 0 °C for 1 h. The reaction mixture was poured into water (250 mL) portion-wise with stirring; the precipitate was filtered, washed with water several times and dried to give 3-sulfonylchloride derivative 5 yield 90.5%. The respective crude sulfonylchloride was used in the next step without further purification.…”

“…Sulfonamide group forms the bioactive moiety of many therapeutic agents such as diuretics, antidiabetics, antibiotics, and antibacterials [11][12][13][14][15][16]. So, our efforts were directed towards the synthesis of new heterocyclic compounds containing pyridazine moiety with anticipated biological activities.…”

Synthesis, Fastness and Spectral Properties of Some New Azo Pyrazole and Pyrazolotriazole Derivatives

“…5 The pyrazole synthesis of particular use because there are themselves building block for a variety of pyrazole containing structure such as pyrazoloisoquinolines, 6 pyrazolopyrimidines, 7 pyrazolopyridines , 8 pyrazolopyrazines 9 and pyrazolotriazoles. 10 Some azopyrazole derivatives have many applications in dyes.…”

Synthesis, Anti-inflammatory and Antibacterial Activities of Novel Pyrazolo[4,3-<i>g</i>]pteridines

“…1,2) Their synthesis has increased noticeably in recent years owing to their diverse biological activities such as antimicrobial and antiparasitic ones. [3][4][5] In continuation to our research work on the synthesis of new pyrazole-based heterocycles with potential biological activities as antimicrobial, [6][7][8][9][10][11][12] as anticonvulsant, 13,14) as β 1 -adrenergic blocking agents, 15) we wish to report herein the synthesis of some novel pyrazolo [4,3-g] pteridines and evaluating their anti-inflammatory and antibacterial activities. bered lactone and also showed the disappearance of absorption bands of the acidic OH and NH 2 groups and that refers to its involvement in the cyclization process.…”