Synthesis and Antimicrobial Activity of Novel 3-Benzyloxy-4-Substituted-2- Azetidinones: Formation of a Hydrophobic Layer Via a Self-Organization Effect

Abstract

We report the synthesis of new persulfide-spacer N-substituted-2-azetidinone-Dglucosamine in an attempt to potentially provide new antibiotics. The Schiff base ligands considered for this study were derived representative example, demonstrated a super hydrophobic layer formed via highly organized thioether spacers on gold as the adsorbate system through the formation of sulfur-gold bonds. The reported glucosides showed a moderate antifungal activity against Candida albicans while being slightly to moderately active against gram-positive and gram-negative bacteria used in this investigation at a concentration of 1 mg/mL dissolved in dimethyl sulfoxide.

Antibacterial and β‐Lactamase Inhibitory Activity of Monocyclic β‐Lactams

“…later reported d ‐glucosamine monocyclic β‐lactam derivatives in which the sugar hydroxyl groups were derivatized with the 3‐(hydroxylthioethyl)propyl moiety, forming thioether spacers. The compounds thus synthesized exhibited slight to moderate antibacterial activity and a broad spectrum of antifungal activity against C. albicans …”

“…The compounds thus synthesized exhibited slight to moderate antibacterial activity and a broad spectrum of antifungal activity against C. albicans. 177…”