Synthesis and Antimicrobial Activity of Some Novel Heterocyclic Candidates via Michael Addition Involving 4-(4-Acetamidophenyl)-4-oxobut-2-enoic Acid

El‐Hashash, M. A.; Essawy, A.; Fawzy, Ahmed Sobhy

doi:10.1155/2014/619749

Cited by 6 publications

(4 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…40 Another compound, €-2-methyl-5-((1S,2R,4R)-2-m ethyl-3-methylbocyclo[2,2,1]-heptane-2-yl)-pent-2-enoic acid was identified through NIST library, which showed promising antibacterial activity as mentioned in literature. 41 Third compound, identified through GC-MS, 3-(1-Benzyl-1Himidazol-2-yl)-5-methylisoxazole, is an aromatic aldehyde which also displayed antibacterial activity as per the report cited in literature. 42 These three compounds individually exhibit good antibacterial activity, however presence of these three compounds combinely in a single plant may increse its antibacterial activity.…”

Section: Zone Of Inhibition Of Negative Control (In Mm)mentioning

confidence: 76%

Separation of Bio-active Compounds and in vitro Antibacterial Potency of Callistemon linearis Floral Extract with Mechanism of Action

Das¹,

Chandra²

2023

Ind. J. Pharm. Edu. Res.

View full text Add to dashboard Cite

Introduction: Infection caused by bacteria is treated with antibiotics which caused several side effects in human and animals. This problem enforced scientist to work out plant originated compounds for treatment of several disease caused by morbific bacteria. Objectives: Present work revealed isolation of bioactive phytocompounds from different fractions of Callistemon linearis flower ethanol extract by chromatographic technique and determination of their antibacterial potency against selected bacteria with mode of action in vitro. Materials and Methods: Antibacterial potency of four different fractions of ethanol extract were done quantitatively via Agar well diffusion method along with determination of Minimum Inhibitory Concentration, and Minimum Bactericidal Concentrations. Further, phytochemical analysis, Fourier Transform Infrared spectroscopic analysis, thin Layer Chromatography separation and Gas Chromatography Mass Spectroscopy analysis of bioactive fractions were done simultaneously to assess the presence of bioactive phytocompounds responsible for the antibacterial potency of the fractions. Time-kill assay, Nucleic acid and protein leakage assay, and FESEM study were employed to determine the mode of activity of the isolated active phytocompounds on the tested bacteria. Results: Maximum antibacterial activity was observed in NHEX of ethanol extract against Escherichia coli (MTCC 739). Chromatographic separation of NHEX detected several bioactive compounds. Assessment of Time-kill assay in treated and untreated bacterial strains determined that bioactive compound of NHEX was bactericidal in nature. Nucleic acid and protein leakage assay of bacterial cells with isolated active compound showed cell damages and FESEM images strongly ascertained this data. Conclusion: The C. linearis floral floral extract possesses antibacterial activities against selected pathogens and causes cellular damages.

show abstract

Section: Zone Of Inhibition Of Negative Control (In Mm)mentioning

confidence: 76%

Separation of Bio-active Compounds and in vitro Antibacterial Potency of Callistemon linearis Floral Extract with Mechanism of Action

Das¹,

Chandra²

2023

Ind. J. Pharm. Edu. Res.

View full text Add to dashboard Cite

show abstract

“…The infrared spectrum of the schiff base ligand has a broad absorption band at 3456 cm −1 which were due to the phenolic group [18,19]. The spectrum displays also medium band at 1290 cm −1 due to υ C-O (phenolic group) [20].…”

Section: Resultsmentioning

confidence: 99%

Biosynthesis of Zinc Nanocomplex Employing for Plant Growth Promotion and Bio-Control of Pythium ultimum

Moustafa¹,

Taha²

2022

New Generation of Organic Fertilizers

View full text Add to dashboard Cite

Green Biosynthesis method was used for the preparation of Zn(II) nano complex from the reaction of the schiff base ligand 2,2′-((1E,1′E)-(1,2-phenylenebis (azanylylidene)) bis(methanylylidene))bis(4-bromophenol) and Zn(II)sulphate. The nano complex was characterized by different physicochemical methods. Zinc nanoparticles (ZnNP-T) will be studied as an antifungal agent. In this study, we will investigate the ability of the myogenic Zinc nanoparticles for plant Growth Promotion and Bio-control of Pythium ultimum.

show abstract

“…By careful comparison of the spectrum of the nano-metal complex with those of the Schiff base ligand, it was found that the band at 3456 cm −1 shifted to lower frequency region at 3401 cm −1 in the metal nano The IR spectrum of the ligand was compared with those of its metal complex to confirm the mode of bonding, as demonstrated in Table 3. The infrared spectrum of the schiff base ligand has a broad absorption band at 3456 cm −1 , which was due to the phenolic group [15,16]. The spectrum also displays medium band at 1290 cm −1 due to υ C-O (phenolic group) [17].…”

Section: Resultsmentioning

confidence: 99%

“…The infrared spectrum of the schiff base ligand has a broad absorption band at 3456 cm −1 , which was due to the phenolic group [ 15 , 16 ]. The spectrum also displays medium band at 1290 cm −1 due to υ C-O (phenolic group) [ 17 ].…”

Section: Resultsmentioning

confidence: 99%

Mycogenic Nano-Complex for Plant Growth Promotion and Bio-Control of Pythium aphanidermatum

Moustafa

Taha

2021

Plants

View full text Add to dashboard Cite

(1) Background: biological way is one of the most ecofriendly and safe strategies for nanomaterials synthesis. So, biosynthesis-green method was used for the preparation of Zn(II) complex (in the Nano scale) from the reaction of the schiff base ligand 2,2’-((1E,1’E)-(1,2-phenylenebis (azanylylidene)), bis(methanylylidene))bis(4-bromophenol), and Zn(II)sulphate. The biogenic ZnNP-T was characterized by different methods. Our purpose was to evaluate the ability of biosynthesis-green method for the preparation of Zn(II) complex as an antifungal agent against diseases from fungal species. (2) Methods: in this work, isolates of Pythium aphanidermatum and Trichderma harzianum were obtained, and Trichderma harzianum was used to prepare nano metal complex. We tested the pathogenicity of nano metal complex against seedling and germination of seeds, and we evaluated the effectiveness of ZnNP-T for growth promotion of Vicia feba in early stage and inhibitory activity against Pythium aphanidermatum. (3) Results: antagonistic activity of ZnNP-T was tested in vitro against Pythium aphanidermatum, and then the growth rates of Vicia faba were determined. The obtained data revealed that mycelial growth of pathogenic fungus was inhibited about 73.8% at 20ppm. In addition, improved the total biomass of Vicia faba in the presence of P. aphanidermatum. All concentration of ZnNP-T positively affected root weight of Vicia faba seedlings, and positively affected shoot weight. Root and shoot lengths were affected by using 20 ppm of ZnNP-T with up to 180 and 96.5 mm of shoot and root length compared to that of the control, while germination percentage was significantly enhanced with up to 100% increase after 72 h of germination. (4) Conclusion: one of the modern challenges in vegetable or fruit production is to enhance seed germination and to grow healthy plants with strong root system. In future, there should be a focus on using of biogenic Zinc nano-complex as plant growth promoter agents.

show abstract

Synthesis and Antimicrobial Activity of Some Novel Heterocyclic Candidates via Michael Addition Involving 4-(4-Acetamidophenyl)-4-oxobut-2-enoic Acid

Cited by 6 publications

References 39 publications

Separation of Bio-active Compounds and in vitro Antibacterial Potency of Callistemon linearis Floral Extract with Mechanism of Action

Separation of Bio-active Compounds and in vitro Antibacterial Potency of Callistemon linearis Floral Extract with Mechanism of Action

Biosynthesis of Zinc Nanocomplex Employing for Plant Growth Promotion and Bio-Control of Pythium ultimum

Mycogenic Nano-Complex for Plant Growth Promotion and Bio-Control of Pythium aphanidermatum

Contact Info

Product

Resources

About