Synthesis and Antimicrobial Activity of Quinazolinone Conjugated Peptides

Suresha, G.P.; Prakasha, K. C.; Kapfo, Wethroe; Gowda, D. Channe

doi:10.1155/2010/979675

Cited by 7 publications

(5 citation statements)

References 8 publications

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“…enthusiastically embarrassed mass spectroscopy to identify and characterize molecule Mass spectrum of the compound is a plot which represents the intensities of the signals at various m/z value [42][43] . It is highly characteristic of the compound ,no two compounds can have similar mass spectra.…”

Section: Mass Spectrum Of Glz-au Complexmentioning

confidence: 99%

Synthesis, Characterization and Spectral Studies of Gold Complex with Gliclazide, An Oral Antidiabetic Allopathic Drug

Krishan¹,

Prakash²,

Mossalamy³

2013

Orientjchem.

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Synthesis, characterization and spectral studies of gold complex with gliclazide, an oral antidiabetic drug have been studied. The conductometric titration using monovariation method indicate that complexes are non-ionic and L 2 M type. Analytical data agrees with the molecular formula(C 15 H 20 N 3 O 3 S) 2 Au. Structure of complex was assigned tetrahedral, supported by IR, 1 H-NMR.X-Ray and Mass studies. Structure (II) is proposed for complex.

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Section: Mass Spectrum Of Glz-au Complexmentioning

confidence: 99%

Synthesis, Characterization and Spectral Studies of Gold Complex with Gliclazide, An Oral Antidiabetic Allopathic Drug

Krishan¹,

Prakash²,

Mossalamy³

2013

Orientjchem.

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“…The peptides alone were the least hydrophobic and inactive towards the bacterial strains, but an enhanced activity even greater than that of the commercial drug was reported when the peptides were conjugated with the heterocyclic compound. It was also observed that an increase in the length of the peptide chain, variation in polarity and hydrophobicity of the molecules were responsible for increased antimicrobial activity [ 116 ].…”

Section: Conjugated or Hybrid Moleculesmentioning

confidence: 99%

Conjugation as a Tool in Therapeutics: Role of Amino Acids/Peptides-Bioactive (Including Heterocycles) Hybrid Molecules in Treating Infectious Diseases

et al. 2023

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Peptide-based drugs are gaining significant momentum in the modern drug discovery, which is witnessed by the approval of new drugs by the FDA in recent years. On the other hand, small molecules-based drugs are an integral part of drug development since the past several decades. Peptide-containing drugs are placed between small molecules and the biologics. Both the peptides as well as the small molecules (mainly heterocycles) pose several drawbacks as therapeutics despite their success in curing many diseases. This gap may be bridged by utilising the so called ‘conjugation chemistry’, in which both the partners are linked to one another through a stable chemical bond, and the resulting conjugates are found to possess attracting benefits, thus eliminating the stigma associated with the individual partners. Over the past decades, the field of molecular hybridisation has emerged to afford us new and efficient molecular architectures that have shown high promise in medicinal chemistry. Taking advantage of this and also considering our experience in this field, we present herein a review concerning the molecules obtained by the conjugation of peptides (amino acids) to small molecules (heterocycles as well as bioactive compounds). More than 125 examples of the conjugates citing nearly 100 references published during the period 2000 to 2022 having therapeutic applications in curing infectious diseases have been covered.

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“…Substituted 4(3H) quinazolinones possess a wide rang of pharmacological activities such as antimicrobial [1,2], anticancer [3], antiviral [4], anti-inflammatory [5], antitubercular [6], antitumor [7], antioxidant [8] and anticonvulsant [9].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and biological evaluation of new quinazolinone derivatives

et al. 2014

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KEYWORDSNew N-substituted-2-methyl quinazolin-4(3H)-ones derivatives comprising 1,3,4-thiadiazole, Schiff bases and 2-azetidinone moieties are reported. The structures of the newly prepared compounds were confirmed by FT-IR and 1 H NMR spectra. The compounds were also evaluated for their antimicrobial, antioxidant and study of inhibition on some enzymes activities. The results suggest that the compounds possess broad spectrum of in-vitro antimicrobial activity. Antioxidant results obtained into the present study indicate that compound 5 show moderate better scavenging activity. Compound 5 demonstrated inhibitory effects on GOT, GPT, GGT and ALP activities, and these effects increase with increasing the concentration of the compound.Schiff bases Azetidinone Quinazolinone Enzymes activities Antioxidant activity Antimicrobial activity

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Synthesis and Antimicrobial Activity of Quinazolinone Conjugated Peptides

Cited by 7 publications

References 8 publications

Synthesis, Characterization and Spectral Studies of Gold Complex with Gliclazide, An Oral Antidiabetic Allopathic Drug

Synthesis, Characterization and Spectral Studies of Gold Complex with Gliclazide, An Oral Antidiabetic Allopathic Drug

Conjugation as a Tool in Therapeutics: Role of Amino Acids/Peptides-Bioactive (Including Heterocycles) Hybrid Molecules in Treating Infectious Diseases

Synthesis and biological evaluation of new quinazolinone derivatives

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