Synthesis and antimicrobial activity of some polymers derived from modified amino polyacrylamide by reacting it with benzoate esters and benzaldehyde derivatives

Abstract

Functionalized polymers have gained much interest in the last decades. This is due to their functional groups and their polymer nature, which give them unique properties and more advantages than the corresponding small molecules. In this trend, we modified polyacrylamide by introducing an amino group in the side chain of the polymer by reacting it with ethylenediamine. The aminemodified polymer was reacted with two classes of active compounds. The first group is aromatic aldehydes containing active groups such as p-hydroxybenzaldehyde, vanillin, p-chlorobenzaldehyde, and anisaldehyde. The second group is phenolic ester derivatives such as p-hydroxymethylbenzoate, 2,4-dihydroxymethylbenzoate, 2-hydroxymethylbenzoate and 3,4,5-trihydroxypropylbenzoate. The antimicrobial activity of these two classes were explored by cut plug method against Candida albicans SC5314, Aspergillus flavus, and Fusarium oxysporium as fungal organisms and Bacillus subtilis, Escherichia coli, and Staphylococcus aureus as bacterial organisms. It was found that the diameter of inhibition zone varied according to the active group in the modified polymer and the examined microorganism. In general, the modified polymers showed antimicrobial activity against the tested microorganisms. However, the polymer derivative of p-chlorobenzaldehyde being the most effective on bacteria and fungi species.

Preparation and characterization of poly(2-hydroxyethyl methacrylate)/ Na-montmorillonite intercalated nanocomposites

“…Poly-HEMA (PHEMA) is a favorable biomaterial because of its excellent biocompatibility and physicochemical properties similar to those of living tissues [5] . The polymerization of hydrophilic polymer such as PHEMA also improves the biodegrading properties [6,7] .…”

Synthesis and evaluation of polyacrylamides derived from polycyclic pendant naphthalene, indole, and phenothiazine based chalcone moiety as potent antimicrobial agents

“…The various synthetic compounds consist of favorable functional groups such as chalcone, amide, phosphonium, and quaternary ammonium units which offer active sites for the microbial pathogens and further act as disinfectants . This kind of functional group‐incorporated compounds is widely used to synthesize several biopolymers for the treatment against the bacterial and fungal‐affected diseases in living beings . The main advantages of these antimicrobial polymeric materials are being thermally and chemically stable, non‐volatile, and non‐permeable through the mammalian skin and also eco‐friendly to the environment .…”

Preparation of Polycyclic Pendant Chalcone Moiety Based Antimicrobial Polyacrylamides

“…Moreover, it is often reported that these groups significantly enhance their antimicrobial activities. 26 Antimicrobial agents such as phenols, naphthalene, anthracene, and fluorene derivatives interact with the surface of the cell and lead to cell death through disintegration of the cell membrane of microorganisms. [27][28][29][30][31] The existence of C=O, C=C, and -NH 2 functional groups in a polyacrylamide molecular chain along with phenyl, naphthyl, and thiophene molecules possesses an enormous biological applications.…”