Synthesis and antimicrobial activity of some new 4H-pyrrolo[1,2-a]benzimidazoles

Abstract

Some new 4H-pyrrolo[1,2-a]benzimidazoles(2a-2f) have been synthesized. The structures of these compounds were confirmed by IR, 1 H NMR, mass spectroscopy and elemental analysis. Compound 2a was further confirmed by X-ray diffraction. The in vitro antimicrobial activities of these compounds were determined against some gram-positive bacteria, gram-negative bacteria and fungi and their drug-resistant isolates in comparison with standard drugs. Antimicrobial results indicate that compounds 2c, 2d and 2e show moderately active antibacterial properties, their minimum inhibitory concentrations are from 12.5 μg/mL to 125 μg/mL. In the series, the most active compound against C. albicans is compound 2f with an MIC value of 31.25 μg/mL.

Biocontrol Potentials of Antimicrobial Peptide Producing Bacillus Species: Multifaceted Antagonists for the Management of Stem Rot of Carnation Caused by Sclerotinia sclerotiorum

“…Moreover, the extract inhibited he growth of Aspergillus niger and Penicillium roqueforti (Black et al, 2013). Pyrrolo is also known to have antifungal activity (Jiang et al, 2014). Hexadecenoic acid has been reported with antifungal activity against Aspergillus, Penicillium , and Fusarium species (Marrez and Sultan, 2016).…”

<i>Bacillus amyloliquefaciens</i> (VB7) with Diverse Antimicrobial Peptide Genes:A Potential Antagonist for the Management of Fairy Ring Spot in Carnations

“…Moreover, the extract inhibited the growth of Aspergillus niger and Penicillium roqueforti 35 . Pyrrolo is also known to have antifungal activity 36 . Hexadecenoic acid has been reported with antifungal activity against Aspergillus, Penicillium and Fusarium species 37 .…”

Regenerating the cell resistance of micromolded PEG hydrogels

“…PEG hydrogels have been illustrated to undergo oxidation reactions that result in loss of the non-fouling character thus spurring on the development of more stable non-fouling materials such as zwitterionic polymers, mixed-charge polymers, and the polyIJ2-methyl-2-oxazoline) polymers. [42][43][44][45][46][47] Some may argue that it is PEG degradation that is enabling the cell migration in this system. However, the oxidation of the PEG gels does not pose a problem over relatively short in vitro experiments such as what are described here.…”