Synthesis and antimicrobial activity of metal complexes from 2-(1’/2’-hydroxynaphthyl)benzoxazoles

Kumar, Anil; Kumar, Devinder

doi:10.3998/ark.5550190.0008.e12

Cited by 23 publications

(4 citation statements)

References 4 publications

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“…8 Finally, certain complexes of Mg(II), Ni(II) and Mn(II) exhibited potent anti-fungal activity against Candida albicans and Aspergilus ficuum. 7,9,10…”

Section: Anti-microbial Activity Of Transition Metal Complexesmentioning

confidence: 99%

FAB, ESI and MALDI Mass Spectrometric methods in the study of metallo-drugs and their biomolecular interactions

Petković

Kamčeva

2011

Metallomics

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This review surveys the soft ionisation mass spectrometric methods that are most commonly used for the investigation of the mechanism of interaction between metallo-drugs and biomolecules. In the first part of the review, an overview of the applications of transition metal complexes in the therapy of various diseases (arthritis, cancer, diabetes) is given, whereas the second part focuses on the obtained results dealing with various aspects of the interaction between metal complexes and different types of biomolecules. Possibilities and limitations of each mass spectrometric method-namely, fast atom bombardment (FAB), electrospray ionisation (ESI) and matrix-assisted laser desorption and ionisation (MALDI)--are discussed in the third part of this review along with the examples of their application for the analysis of metal complexes, as well as of the products of their interaction with biomolecules.

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“…8 Finally, certain complexes of Mg(II), Ni(II) and Mn(II) exhibited potent anti-fungal activity against Candida albicans and Aspergilus ficuum. 7,9,10…”

Section: Anti-microbial Activity Of Transition Metal Complexesmentioning

confidence: 99%

FAB, ESI and MALDI Mass Spectrometric methods in the study of metallo-drugs and their biomolecular interactions

Petković

Kamčeva

2011

Metallomics

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“…Nowadays, the coordination chemistry of oxygen donor ligands is viewed as an active research area. Over the last few years, metal complexes have been widely investigated for their antimicrobial [3,4], antitubercular [5,6], antiviral [7], anticonvulsant [8,10], antitumor [11,12], and anti-inflammatory activities [13,14].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Cu(II) Schiff base complexation and structural annalysis of the ligand 4-{[2-(methoxycarbonyl) pyrrolidin-1-yl] methyl} benzoic acid

Far¹,

Benaissa²,

Daoudi³

et al. 2023

J. Fundam and Appl Sci.

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A new proline based ligand was syn thesized by a convenient procedure. The ligand was characterized by 1 H NMR, 13 C NMR and IR spectroscopies. Copper (II) Schiff base complexes of 4 --{[2 --(methoxycarbonyl) pyrrolidin 1 yl] methyl} benzoic acid of this ligand were synthesized and characterized by the aforementioned spectroscopy techniques, i.e. 1 H NMR, 13 C NMR and IR. Moreover, its bactericidal activity was assessed through the determination of the minimum inhibitory concentration (MIC) values as well as the i nhibition zone diameter for gram po sitive bacteria, such as Staphylococcus aureus , and gram negative bacteria like Klebsiella pneumoniae, Citrobacter freundii, Salmonella typhi, Enterobacter cloacae (the two bacteria Citrobacter freundii and Salmonella typhi are very sensitive against this molecule unlike Enterobacter cloac ae bacteria which is resistant).

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“…The considerable biological activities of benzoxazole [3,8,9] compounds in drug discovery and their importance in the medicinal field have stimulated the present investigation on the synthesis of derivatives of this ring system along with the substitutions like sulfonamide, nitro and chloro. Hence, it was planned to synthesize fused benzoxazole derivatives.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, In-vitro Antioxidant, Anti-diabetic Evaluation and Docking Studies of Newly Synthesized Benzoxazole Derivatives

Rodrigues¹,

Bennehalli²,

Manjappaiah

et al. 2021

Trends Sci

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In the present study, a set of different benzoxazole derivatives has been synthesized from ethyl acetoacetate, ethoxymethylene malononitrile, NaNO2, and organic acids. Analytical instruments like proton NMR (1H), carbon NMR (13C), infrared spectroscopy (IR), and LC-MS mass spectrometry were used for structural characterization. Synthesized molecules were evaluated for In-vitro antioxidant property (DPPH assay, Total antioxidant & reducing power method) and anti-diabetic property (alpha-amylase & alpha-glucosidase assay). In silico, studies against Human pancreatic alpha-amylase (PDB ID: 3BAW) have been carried out to get the binding approach of the ligand towards the protein. The results demonstrated that compounds namely 5b, 6b, 3b and 4b had potent antioxidant and anti-diabetic activity compared with ascorbic acid and acarbose. HIGHLIGHTS Anti-oxidant (DPPH assay, Total antioxidant and Reducing power) and Anti-diabetic (alpha-amylase & alpha-glucosidase assay) activities performed for synthesized molecules Sulfonamide substitutions are more potent towards biological activities In silico docking studies correlate with in vitro studies The small three-dimensional, stable structure and its ability to form hydrogen bonding the molecules show good activity towards antioxidant and anti-diabetic GRAPHICAL ABSTRACT

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Synthesis and antimicrobial activity of metal complexes from 2-(1’/2’-hydroxynaphthyl)benzoxazoles

Cited by 23 publications

References 4 publications

FAB, ESI and MALDI Mass Spectrometric methods in the study of metallo-drugs and their biomolecular interactions

FAB, ESI and MALDI Mass Spectrometric methods in the study of metallo-drugs and their biomolecular interactions

Synthesis, Cu(II) Schiff base complexation and structural annalysis of the ligand 4-{[2-(methoxycarbonyl) pyrrolidin-1-yl] methyl} benzoic acid

Synthesis, In-vitro Antioxidant, Anti-diabetic Evaluation and Docking Studies of Newly Synthesized Benzoxazole Derivatives

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