Synthesis and Antimicrobial Activity of Some New 1-[4-(4-Fluorobenzoylamino) Benzoyl)-4-Substituted Thiosemicarbazides

Abstract

1-Aroyl-4-substituted thiosemicarbazides were obtained by the addition of 4-(4-fluorobenzoylamino)benzoylhydrazine to methyl, ethyl, propyl, allyl, cyclohexyl, phenyl and phenethyl isothiocyanates. The structures of the synthesized compounds were confirmed using UV, IR, 1H-NMR (for compounds 4c, 4g) and mass (for compounds 4b, 4c, 4g) spectral methods together with elemental analyses. None of the synthesized compounds has been reported previously.

Novel 1,2,4-triazoles derived from Ibuprofen: synthesis and in vitro evaluation of their mPGES-1 inhibitory and antiproliferative activity

“…Refluxing compound 1 (commercial phenylacetohydrazide), and compound 2 (Ibuprofen hydrazide) with methyl-/ethylisothiocyanate in ethanol yielded substituted thiosemicarbazides (compounds 3-6, Figs. S5-S15) [25,[35][36][37][38][39][40][41][42][43][44][45]. All cyclization products (compound 7-10, Figs.…”

Synthesis and Anticancer Activity of Tolmetin Thiosemicarbazides

“…N 1 , N 2 and N 4 protones which prove the presence of thiosemicarbazides were detected in 1 H-NMR spectrum (Fig 3) and the information given is supported by the literature. (17)(18)(19)(20)(21)(22). 4c, 4e, 4f, 4h), it was determined that these compounds undergo thione-thiol tautomerism (Fig 4).…”

Etodolac Thiosemicarbazides:A novel class of hepatitis C virus NS5B polymerase inhibitors

“…Therefore, the thiosemicarbazide is a highly efficient pharmacophore in molecular design. On the other hand, various derivatives of thiosemicarbazide have been reported to possess interesting biological activities such as antimicrobial (5–8), anticonvulsant (9), antibacterial (10–12), antifungal (13–17), anti-inflammatory (18,19) antiviral (20) and anticancer activities (21–24). In this study, we have explored the therapeutic potential of the thiosemicarbazide scaffold against HCV NS5B.…”