Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers

Güven, Özden Özel; Erdoğan, Taner; Göker, Hakan; Yıldız, Sulhiye

doi:10.1016/j.bmcl.2007.01.061

Cited by 184 publications

(75 citation statements)

References 8 publications

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“…The strong antimicrobial activities of (3) may be caused by the existence of Cl substitute groups, which is considered to be a functional groups for antimicrobial processes. [20] The remaining results are lower than Tetracycline, which may not deserve further investigation. …”

Section: Resultsmentioning

confidence: 91%

Crystal Structures and Antimicrobial Activities of N'-[2,5-Dihydroxybenzylidene]-3,4,5-Trimethoxybenzohydrazide, N'-[2,4-Dichlorobenzylidene]-3,4,5-Trimethoxybenzohydrazide, and 2,4-Dichloro-N'-(2-Hydroxy-3-Methoxy-5-Nitrobenzylidene)benzohydrazide Ethanol Solvate

Han

2013

J. Chil. Chem. Soc.

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Section: Resultsmentioning

confidence: 91%

Crystal Structures and Antimicrobial Activities of N'-[2,5-Dihydroxybenzylidene]-3,4,5-Trimethoxybenzohydrazide, N'-[2,4-Dichlorobenzylidene]-3,4,5-Trimethoxybenzohydrazide, and 2,4-Dichloro-N'-(2-Hydroxy-3-Methoxy-5-Nitrobenzylidene)benzohydrazide Ethanol Solvate

Han

2013

J. Chil. Chem. Soc.

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“…Several benzimidazole derivatives are reported to exhibit antimicrobial, [1][2][3] anticancer, 4,5 antifungal, 6,7 antiparasitic, 8 antiviral, 9 anti-inflammatory, 10 and antihistaminic 11 activities. Therefore, methods for their preparations are important for synthetic organic chemists and biologists.…”

Section: Introductionmentioning

confidence: 99%

Simple, Mild, and Highly Efficient Synthesis of 2-Substituted Benzimidazoles and Bisbenzimidazoles

Eren

Bekdemi̇r

2014

Química Nova

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A new convenient method for preparation of 2-substituted benzimidazoles and bis-benzimidazoles is presented. In this method, o-phenylenediamines were condensed with bisulfite adducts of various aldehydes and di-aldehydes under neat conditions by microwave heating. The results were also compared with results of synthesis by conventional heating under reflux. Structures of the products were confirmed by infrared, 1 H-and 13 C-NMR spectroscopy. Short reaction times, good yields, easy purification of products, and mild reaction conditions are the main advantages of this method.

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“…Several bioactive compounds with this heterocyclic unit have valuable pharmacological properties such as antiparasitic [19], antifungal [20], antimicrobial [21,22] and antidepressant [23] activity, among others. In this context, 2,4,5-triarylimidazole compounds have gained remarkable importance due to their widespread biological activities and their applicability in synthetic organic chemistry.…”

Section: Introductionmentioning

confidence: 99%

Article Synthesis and Trypanocidal Activity of Novel 2,4,5-Triaryl-N-Hydroxylimidazole Derivatives

et al. 2013

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Herein, we report the design, synthesis and trypanocidal activity of some novel trisubstituted imidazole derivatives. These heterocyclic derivatives were structurally planned by exploring the concept of molecular hybridisation between two arylhydrazones derived from megazol, which has potent trypanocidal activity. The trypanocidal activity of these triarylimidazole derivatives was evaluated against infective trypomastigote forms of OPEN ACCESSMolecules 2013, 18 3446T. cruzi and the derivative 2'-(4-bromophenyl)-1-methyl-5'-phenyl-1H,3'H-2,4'-biimidazol-3'-ol showed moderate biological activity (IC 50 = 23.9 µM) when compared to benznidazole, a standard trypanocidal drug. These compounds did not present cytotoxic effects at concentrations near the trypanocidal IC 50 , being considered a good starting point for the development of new anti-Chagas drug candidates.

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Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers

Cited by 184 publications

References 8 publications

Crystal Structures and Antimicrobial Activities of N'-[2,5-Dihydroxybenzylidene]-3,4,5-Trimethoxybenzohydrazide, N'-[2,4-Dichlorobenzylidene]-3,4,5-Trimethoxybenzohydrazide, and 2,4-Dichloro-N'-(2-Hydroxy-3-Methoxy-5-Nitrobenzylidene)benzohydrazide Ethanol Solvate

Crystal Structures and Antimicrobial Activities of N'-[2,5-Dihydroxybenzylidene]-3,4,5-Trimethoxybenzohydrazide, N'-[2,4-Dichlorobenzylidene]-3,4,5-Trimethoxybenzohydrazide, and 2,4-Dichloro-N'-(2-Hydroxy-3-Methoxy-5-Nitrobenzylidene)benzohydrazide Ethanol Solvate

Simple, Mild, and Highly Efficient Synthesis of 2-Substituted Benzimidazoles and Bisbenzimidazoles

Article Synthesis and Trypanocidal Activity of Novel 2,4,5-Triaryl-N-Hydroxylimidazole Derivatives

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