Synthesis and antimicrobial activity of benzazolyl azolyl urea derivatives

Babu, K. Narendra; Ummadi, Nagarjuna; Reddy, Guda Dinneswara; Padmaja, A.; Padmavathi, V.

doi:10.1016/j.molstruc.2019.126871

Cited by 10 publications

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study aimed to elucidate the biochemical components of adamantinomatous CP cystic fluid with the view of possible antimicrobial components as a follow-up to a previous study that had shown significant antimicrobial activity in the fluid(11)(12)(13). All these biochemical components have different antimicrobial properties among other things(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31).…”

mentioning

confidence: 99%

Biochemical profile of paediatric adamantinomatous craniopharyngiomas: A prospective cohort study

Jokonya

Mduluza-Jokonya²,

Mwale³

et al. 2022

Front. Surg.

View full text Add to dashboard Cite

IntroductionCraniopharyngioma is a rare brain tumour. Despite being histologically benign, it behaves aggressively and is often difficult to manage. Descriptive epidemiological data on the tumour is lacking in sub-Saharan Africa, and there is none for Zimbabwe. The tumour usually has a cystic component that has been raising interest in the past decade. Few studies have looked at the biochemical composition thereof. This study aims to give a landscape view of craniopharyngiomas (CPs) in Zimbabwe and then profile the biochemical properties of the cystic component of paediatric adamantinomatous craniopharyngioma.MethodologyA prospective cohort study was done in Zimbabwe over a 2-year period to study the epidemiological distribution of craniopharyngioma and examine the biochemical composition of adamantinomatous craniopharyngioma cystic fluid in the paediatric population. Fifteen patients were recruited who had craniopharyngiomas, and of those, nine paediatric adamantinomatous craniopharyngiomas had fluid analysed for biochemical components. SPSS statistical package was used to analyse the data. Descriptive statistics were used for epidemiological data.ResultsThe incidence of CP was calculated to be 0.53 per million person-years. Incidence among the paediatric population 0–14 years was 1.2 per 100,000 person-years. Several biological components were found to be elevated significantly compared to serum and cerebral spinal fluid (CSF). These are sodium, potassium, urea, alkaline phosphatase, phosphate, magnesium, albumin, gamma-glutamyl transferase, calcium, low-density lipids, and glucose.ConclusionThe incidence of CP in Zimbabwe is similar to the rest of the world. Some biochemical components have been noted to be markedly elevated in the cystic fluid and were mirroring serum rather than CSF in concentration.

show abstract