Synthesis and Antimicrobial Activity of N-5-Diaryl-7-Methyl-3-OXO-2,3-Dihydro-5H-[1,3]Thiazolo[3,2-a]Pyrimidine-6-Carboxamide Hydrochlorides

Гейн, В. Л.; Замараева, Т. М.; Buzmakova, N. A.; Одегова, Т. Ф.; Gein, L. F.

doi:10.1007/s11094-015-1317-6

Cited by 1 publication

(1 citation statement)

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“…15 Pyrazole-containing compounds have various therapeutic and pharmaceutical properties and represent important building blocks for, insecto-acaricidal, antibacterial, antidepressant, analgesic, antiviral, anticancer, antioxidant, anti-HIV, cyclooxygenase-2 (COX-2) inhibitor, anti-inflammatory, antiproliferative drugs. 16 17 18 19 20 21 22 23 24 25 26 Many of the derivatives are of great interest due to their pharmacological properties, for instance, celecoxib {4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide} acts as inhibitor of COX-2 and reduces side effects in the gastrointestinal tract. Methylthio pyrazole epothilone B shows strong antitumor activity.…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Pyrazoles: Recent Developments in Aqueous Methods

Singh

Yadav²,

Yadav

et al. 2023

SynOpen

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Organic syntheses by adopting green protocols such as sonochemical procedures, microwave technologies, solvent-free conditions, green solvent, heterogeneous catalysis particularly nanocatalysts, ionic liquids have replaced the traditional procedures due to concerns pertaining especially to environment. The heterocycle, pyrazole, due to its multifaceted applications has been the cyanosure of the chemists and therefore various synthetic approaches have been developed to synthesize the pyrazole containing molecules. In the present compilation, we have summarized the recent water-based research work on the synthesis of pyrazoles. Key words: Green chemistry, environment friendly, water based synthesis, pyrazoles

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