Synthesis and Antimicrobial Activity of Some 2-Amino-4-(7- Substituted/Unsubstituted Coumarin-3-yl)-6-(Chlorosubstitutedphenyl) Pyrimidines

Abstract

Purpose: To prepare some 2-amino-4-(7-substituted/unsubstitutedcoumarin-3-yl)-6-(chlorosubstitute dphenyl) pyrimidines as antimicrobial agents. Methods:Some 2-amino-4-(7-substituted/unsubstitutedcoumarin-3-yl)-6-(chlorosubstitutedphenyl) pyrimidines were prepared by reacting 3-chlorosubstitutedphenyl-1-(7-substituted/unsubstituted coumarin-3-yl)

Synthesis and Evaluation of Antimicrobial Activity of Some 2-Morpholinomethylamino-4-(7-Unsubstituted/Substituted Coumarin-3-yl)-6-Chlorosubstitutedphenyl Pyrimidines

“…The characteristic peaks in 1 H-NMR spectra that confirmed the formation of the compounds (1a-18a) from the compounds (1-18) [25] were the appearance of the signals at δ (ppm) values from 2.63 to 2.72 for the four protons of -CH 2 -N-CH 2 -portion of the morpholine moiety; from 3.50 to 3.58 for the four protons of -CH 2 -O-CH 2 -portion of the morpholin moiety; and from 4.27 to 4.42 for the two methylene protons of -NH-CH 2 -moiety. The compounds (1a-18a) were tested for their in vitro antimicrobial activity by serial plate dilution method [27,28] against five Grampositive bacteria; five Gram-negative bacteria; and five fungi.…”

“…2-amino-4-(7-substituted/unsubstituted coumarin-3-yl)-6-(chlorosubstitutedphenyl) pyrimidines (1-18) prepared according to our previous report [25] were reacted with morpholine and formaldehyde in absolute ethanol to provide the title compounds (1a-18a).…”

“…A number of morpholine containing chemical compounds have also been reported as antimicrobial agents [17][18][19][20][21][22]. Encouraged by these observations and also in continuation of our search for potent antimicrobial agents [23,24] including antimicrobial agents having coumarin moiety [25,26], we decided to prepare some 2-morpholinomethylamino-4-(7-unsubstituted/substitutedcoumarin-3-yl)-6-chlorosubstitutedphenyl pyrimidines, herein after the title compounds (1a-18a), as antimicrobial agents.…”

Synthesis, Antimicrobial and Anticancer Activities of 5-(4-Substituted-Phenyl)-1,3,4- Thiadiazole-2-Amines

“…The synthesized compounds 4(a-h) were evaluated for antibacterial activity against Staphylococcus aureus (MTCC7443; Gram+ve), Bacillus subtilis (MTCC121; Gram+ve), Escherichia coli (MTCC118; Gram-ve) and Pseudomonas aeruginosa (MTCC424; Gram-ve) bacterial strains 25,26 . While, the antifungal activity was tested against two fungi, Aspergillus niger and Candida albicans by disc diffusion technique 26,27 .…”

“…While, the antifungal activity was tested against two fungi, Aspergillus niger and Candida albicans by disc diffusion technique 26,27 . Concentrations of standard drugs, Fluconazole and Ciprofloxacin (20 µg/mL) were used for antifungal activity and antibacterial activity, respectively.…”