Synthesis and antimicrobial activity of a water-soluble chitosan derivative with a fiber-reactive group

Lim, Sang‐Hoon; Hudson, Samuel M.

doi:10.1016/j.carres.2003.10.024

Cited by 627 publications

(312 citation statements)

References 20 publications

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“…Similar features of the IR spectra were observed in other studies on quaternized chitosan. 43,44,46 The adsorptive capability of ChGpGl microspheres toward heparin, both in terms of the rate of adsorption and the amount of heparin adsorbed per unit weight of microspheres, was dramatically improved by quaternization of ChGp microspheres. Figure 12 shows a comparison of heparin adsorption by the same amounts of ChGp and ChGpGl microspheres.…”

Section: Resultsmentioning

confidence: 99%

pH-Sensitive Genipin-Cross-Linked Chitosan Microspheres For Heparin Removal

et al. 2008

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Chitosan hydrogel microspheres were obtained by cross-linking chitosan in its inverse emulsion using genipin as cross-linker. The genipin-cross-linked chitosan microspheres (ChGp) swell significantly in water at pH values below 6.5 and shrink to a smaller extent at pH values above 6.5. ChGp microspheres bind heparin in water. The kinetics of heparin binding was found to be pH dependent and was faster and more efficient at a lower pH. That can be also controlled by the weight of ChGp microspheres used. Rate and efficiency of heparin adsorption at pH 7.4, which is typical of blood, could be increased by quaternization of ChGp microspheres using glycidyltrimethylammonium chloride (GTMAC). The polymeric material obtained thus can be potentially useful for heparin removal in biomedical applications.

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Section: Resultsmentioning

confidence: 99%

pH-Sensitive Genipin-Cross-Linked Chitosan Microspheres For Heparin Removal

et al. 2008

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“…After each sampling, the same volume of fresh phosphate buffer was added to the receiver compartment to maintain the constant volume. in the primary amine of chitosan (Figure 2a) [14] , but they were weaken in chitosan-agarose microspheres and the new absorption band at 1650 cm -1 appeared (Figure 2d), which could be attributed to the interaction between the -CHO groups of glutaraldehyde and the -NH 2 groups of chitosan in microspheres [15] . As shown in Figure 2b, the characteristic absorption bands of agarose were observed at 1076 cm -1 (C-O, axial deformation), 933 cm -1 (characteristic of 3, 6-anhydrogalactose) and 889 cm -1 (attributed to C-H angular deformation of anomeric carbon) [16] .…”

Section: Evaluation Of In Vitro Drug Releasementioning

confidence: 99%

Preparation of berbamine loaded chitosan-agarose microspheres and in vitro release study

Zhang

Yang

2012

Polímeros

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Berbamine loaded chitosan-agarose microspheres were prepared using a water-in-oil emulsion technique. Optimum preparing parameters were determined by orthogonal experiments as follows: ratio of berbamine to chitosan (w/w) is 1:10; percentage of emulsifier (span 80, v/v) is 6%; volume of glutaraldehyde is 2 mL; and reaction temperature is 70 °C. Under these optimal conditions, the encapsulation efficiency and loading capacity of microspheres are 84.57% and 8.44%, respectively. The swelling tests showed that the microspheres possessed higher swelling ratio at pH 7.4 than at pH 1.2. FTIR indicated that berbamine had been successfully loaded in the chitosan-agarose microspheres by physical entrapment. In vitro release studies showed that berbamine was released from microspheres in a significantly sustained fashion.

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“…To overcome this pH limitation, many researchers are exploring water-soluble chitosan via chemical modification (Shahidi et al 1999;Varma et al 2004;Guo et al 2007;Anitha et al 2009). Due to its outstanding water solubility and antibacterial property (Suzuki et al 2000;Lim and Hudson 2004), introduction of quaternary ammonium salts onto the chitosan backbone will be one of the best methods.…”

Section: Introductionmentioning

confidence: 99%

“…But the same problem is the hazardous and high-cost reagent-iodomethane. In addition to the above methods, 2-hydroxypropyl trimethylammonium chloride chitosan (HACC), was prepared by reacting chitosan with glycidyltrimethylammonium chloride (GTAMC) in a neutral condition (Lim et al 2004). As a quaternization reagent, GTAMC is easy to react with amino groups of chitosan.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of 2-Hydroxypropyl Trimethylammonium Chloride Chitosan and its Application in Bamboo Fiber Paper

Yuan¹,

Dang²,

Pu³

2017

BioResources

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To obtain a functional composite paper with antibacterial activity, 2-hydroxypropyl trimethylammonium chloride chitosan (HACC) was prepared and sprayed onto the surface of paper made of bamboo fiber. HACC was synthesized from chitosan with 2,3-epoxypropyl trimethylammonium chloride (GTAMC), and the optimal preparation conditions were selected by single-factor tests. The highest degree of substitution (DS) of HACC reached 0.868, when the ratio of chitosan to GTAMC was 1:4, and the water solubility was noticeably improved. The structural characterization demonstrated the successful modification on the original chitosan with a decrease in heat stability and the peak correlated with hydroxypropyl trimethylammonium chloride groups in FTIR. The addition of HACC in the bamboo fiber paper greatly increased the antibacterial activity, and water absorption was higher as well. These results may serve as a basis for the modification and the preparation of chitosan antibacterial agents.

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Synthesis and antimicrobial activity of a water-soluble chitosan derivative with a fiber-reactive group

Cited by 627 publications

References 20 publications

pH-Sensitive Genipin-Cross-Linked Chitosan Microspheres For Heparin Removal

pH-Sensitive Genipin-Cross-Linked Chitosan Microspheres For Heparin Removal

Preparation of berbamine loaded chitosan-agarose microspheres and in vitro release study

Synthesis of 2-Hydroxypropyl Trimethylammonium Chloride Chitosan and its Application in Bamboo Fiber Paper

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