Synthesis and Antimicrobial Activity of 2-Chloro(bromo)-(2-methyl)-3-arylpropionamides

Arylsubstituted Halogen(thiocyanato)amides Containing 4-Acetylphenyl Fragment. Synthesis, Cyclization and Antimicrobial Properties

“…The analysis of antimicrobial activity of the synthesized 3-(4-acetylphenyl)-(2-methyl)-2-chloro (bromo, thiocyanato)propanamides I-III and 5-(4acetylbenzyl)-2-amino-(5-methyl)thiazol-4(5H)-ones IV shows the insignificant increase in their antibacterial and antomycotic activity compared with 2-halogen (thiocyanato)-(2-methyl)-3-phenylpropanamides [10,11]. This regularity is caused most of all by the modification of aromatic nucleus via introducing the acetyl group.…”

“…Previously synthesized halogeno-and thiocyanatoarylation products [7,8] have a sufficiently effective antibacterial and antimycotic activity [9][10][11]. 3-Aryl-(2-methyl)-2-thiocyanatopropanamides are characterized by pronounced anticandidiasis activity [9].…”

Synthesis and Antimicrobial Activity of Products Obtained via Anionarylation of Acrylic and Metahcrylic Acids Amides and Nitriles by 5-Carboxyphenylene-1,3-Bisdiazonium Salts

“…The analysis of antimicrobial activity of the synthesized 3-[3-amino(cyano)-2-chloro(bromo, thiocyanato)-(2-methyl)-3-oxopropyl]-5-chloro(bromo, thiocyanato) benzoic acids I-V shows the essential increase in their antibacterial and antomycotic activity compared with 2-halogen(thiocyanato)-(2-methyl)-3-phenylpropanamides [11,12]. This regularity is caused most of all by the modification of aromatic nucleus via introducing chlorine atom, bromine atom or thiocyanate group together with carboxyl group which considerably increases the molecule hydrophilicity.…”

“…Previously synthesized products [9,10] have sufficiently effective antibacterial and antimycotic activity [11,12]. 2-Thiocyanato-(2-methyl)-3-arylpropanamides are characterized by pronounced anticandidiasis activity [12].…”

The synthesis and the antimicrobial activity of anionarylation products containing the sulfonamide fragment

“…Синтезовані раніше продукти галогено-та тіоціанатоарилювання похідних a,b-ненасичених кислот [11] виявилися достатньо ефективними в плані антибактеріальної та антигрибкової активності [12]. Зокрема, 3-арил-(2-метил)-2-тіоціанатопропанаміди характеризуються яскраво вираженою антикандидозною дією, пригнічуючи ріст штамів C. albicans при концентрації 3,9-7,8 мкг/мл [13].…”