Synthesis and antimicrobial activity of 5-R-benzyl-2-(arylidenehydrazono)thiazolidin-4-ones

Drapak, Іryna; Logoyda, Liliya; Shtoyko, N. Ye.; Sulyma, M.I.; Чабан, Т. І.; Matiychuk, V. S.

doi:10.7124/bc.000a43

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Antimicrobial Activity1

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2021

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“…Chaban et al reported generally weak antimicrobial activity of Compounds 134a-136c. Their percent of growth inhibition (GI) was less than 50%, except Compounds 135d and 136c, that showed GI = 72.4 and 64.4 % against S. aureus [138,139].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

The Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent Studies

Mech

Kurowska

Trotsko

2021

IJMS

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Thiazolidin-4-ones is an important heterocyclic ring system of a pharmacophore and a privileged scaffold in medicinal chemistry. This review is focused on the latest scientific reports regarding biological activities of thiazolidin-4-ones published in 2020 and 2021. The review covers recent information about antioxidant, anticancer, anti-inflammatory, analgesic, anticonvulsant, antidiabetic, antiparasitic, antimicrobial, antitubercular and antiviral properties of thiazolidin-4-ones. Additionally, the influence of different substituents in molecules on their biological activity was discussed in this paper. Thus, this study may help to optimize the structure of thiazolidin-4-one derivatives as more efficient drug agents. Presented information may be used as a practical hint for rational design of new small molecules with biological activity, especially among thiazolidin-4-ones.

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Section: Antimicrobial Activitymentioning

confidence: 99%