Synthesis and Antimicrobial Evaluation of Some Heterocyclic Chalcone Derivatives

Abstract

Some new heterocyclic compounds containing isoxazole, pyrazole and oxadiazole ring systems were prepared from various chalcones. The synthesized compounds have been characterized by elemental analysis and spectral methods. These compounds were screened for their antimicrobial activities.

Thiocarbamoyl in synthesis of the absorbent bis-mono and dimethine cyanine dyes incorporating porphyrin, thiazoles, thiazolones, thiadiazoles, pyrazoles and pyrazolones

“…Also, they are applied extensively in organic composition. 23,24 A lot of efforts have been devoted to synthesize bis-porphyrinodimethine cyanine dye 8 by reaction of compound 7 with two moles of 1-formyl porphyrin in N,N-dimethylformamide in the presence of a catalytic quantity of piperidine under nitrogen gas for 24 h, affording a good yield. Structure of 8 was based on it spectral and analytical analyses.…”

Heterocyclic Synthesis Via Enaminonitriles: One-Pot Synthesis of Some New Pyrazole, Pyrimidine, Pyrazolo[1,5-A]Pyrimidine and Pyrido[2,3-D]Pyrimidine Derivatives

“…The IR spectrum lacked an absorption band due to a CN function and showed bands at 3386, 3161, 1673, 1635 and 1276cm -1 characteristic to 3NH, t wo amidic CO and CS functions., respectively. The 1H NM R spectrum exhibited no signal due to NH2 protons which was attributed to either structures (29), (31) or (33) and displayed doublet signal at  8.24pp m assignable to pyrimid ine-H6 proton, three broad singlet signals at  9.01pp m,  11.07pp m and  11.73pp m, specific for three NH protons, in addit ion to an aromat ic mu ltip let in the reg ion  7.21-7.93pp m.…”

“…It was interesting to synthesis hybrids possessing biological and pharmacological activit ies due to benzimidazo le [16][17][18][19][20][21][22][23][24][25][26][27][28][29] and certain substituted pyrazoles [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] hoping that this combination may possess a potential analgesic activity along with possible anticancer effect.…”

Synthesis, Antiviral Bioactivity of Novel 4-Thioquinazoline Derivatives Containing Chalcone Moiety

“…Chalcones, belonging to the flavonoid family and obtained from Carthamus tinctorius first, possessed a broad spectrum of biological activities, including antibacterial [9][10][11][12], antifungal [13], anti-Alzheimer's disease [14], anticancer [15], antitrichomonal [16], and anti-trypanosomacruzi [17] activities. It is reported that Verma et al, had reported a series of chalcones derivatives, which were used to control plant viruses [18].…”