Synthesis and Antimicrobial of Certain New Thiazolidinone, Thiazoline, and Thiophene Derivatives

Gouda, Moustafa A.; Berghot, M. A.; Shoeib, Alaa; Khalil, A. M.

doi:10.1080/10426500903074858

Cited by 15 publications

(7 citation statements)

References 8 publications

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“…4‐Thiazolidinones are one of the most intensively investigated classes of aromatic five membered heterocycles [ 29–32]. 4‐Thiazolidinone derivatives exhibit broad spectrum of biological activity [ 33–36]. Its derivatives have been found to have potentially chemotherapic activities such as anticonvulsant [ 37], antibacterial [ 38], antifungal [ 39], anti‐inflammatory [ 40], anticancer [ 41], and antipsychotic [ 42] properties.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, antibacterial and antifungal activity of 2‐(aryl)‐3‐(3‐((8‐hydroxyquinolin‐5‐yl)diazenyl)phenyl)thiazolidin‐4‐ones

Chopde

Pagadala

Meshram

et al. 2011

Journal of Heterocyclic Chem

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Abstract5‐((3‐Aminophenyl)diazenyl)quinolin‐8‐ol (1) was synthesized by diazotization reaction and coupled with 8‐hydroxyquinoline moiety. This amine on facile condensation with aromatic aldehydes in presence of glacial acetic acid and ethanol affords anils (2). These anils on cyclocondensation reaction with thioglycolic acid (i.e., mercaptoacetic acid) yield the titled compound (3). The structure of the newly synthesized anils (2) and thiazolidinones (3) has been confirmed by elemental analysis and spectral analysis. The titled compounds have been screened against different bacterial and fungal strains. J. Heterocyclic Chem., (2011).

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Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, antibacterial and antifungal activity of 2‐(aryl)‐3‐(3‐((8‐hydroxyquinolin‐5‐yl)diazenyl)phenyl)thiazolidin‐4‐ones

Chopde

Pagadala

Meshram

et al. 2011

Journal of Heterocyclic Chem

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“…Heating of compound 38 with 29a,b or 24a in DMF/EtOH at reflux in the presence of triethylamine, resulted in the formation of 5-acetyl(or-benzoyl)-4-amino-2-phenylaminothiophene-3carboxamides 39a-c (Scheme 16). 80,81…”

Section: Scheme 15mentioning

confidence: 99%

“…Subsequent reaction of the potassium salt 37 with chloroacetyl chloride 8 in DMF afforded 2-cyano-2-(thiazolidin-2-ylidene)acetamide 125 (Scheme 53). 80…”

Section: Scheme 52mentioning

confidence: 99%

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Synthesis and synthetic applications of cyanoacetamides

Abdelhamid¹,

Ghozlan²,

Abdelmoniem³

et al. 2020

Arkivoc

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Approaches for the preparation of cyanoacetamide derivatives as well as the chemical reactivity profiles and structures of these substances are reviewed. The utility of these compounds as precursors is emphasized in the synthesis of five-and six-membered heterocycles and their fused heterocycles. The reported heterocyclic compounds in this review article are classified according to the kind of the heterocyclic systems.

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“…Pyrazoles also possess antidepressant, anti-inflammatory and anti-rheumatic activities [12][13][14]. In recent years, several thiazole derivatives were found as anticonvulsant activities [15][16][17][18], antioxidant activities [19], potential neuro protective agents [20,21] and anti-tumor agents [22,23]. Also, some pyridones have antibacterial [24], antitumor [25] and other interesting biological activities [26,27].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Anticancer Evaluation of Some New Heterocyclic Scaffolds Incorporating the Acetanilide Moiety

Abdel‐Latif¹,

Keshk²,

Saeed³

et al. 2017

MOCR

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New heterocyclic scaffolds containing acetanilide moiety were synthesized as anticancer agents. The precursor N-(4-acetamidophenyl)-2-cyanoacetamide (3) was coupled smoothly with (un)substituted phenyl diazonium chlorides producing the hydrazones 4. Various 2-pyridones 6 were picked up through the treatment of 3 with different arylidene malononitriles. The precursor underwent reaction with phenyl isothiocyanate in DMF/KOH followed by in situ addition of several α-halogenated reagents afforded the corresponding thiazole derivatives 9 and 10. Heating of thiocarbamoyl scaffold 11 with chloroacetone and phenacyl chloride resulted in the formation of 5substitutedthiophene-3-carboxamides 12. Condensation of the synthesized ketene N,S-acetal 13 with NH 2 NH 2 furnished the corresponding pyrazole-4-carboxamide 14. The newly synthesized scaffolds were characterized by considering their spectral analyses and they evaluated for their in vitro anticancer activities to show promising results. acetamido group increased the anticancer activity

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Synthesis and Antimicrobial of Certain New Thiazolidinone, Thiazoline, and Thiophene Derivatives

Cited by 15 publications

References 8 publications

Synthesis, characterization, antibacterial and antifungal activity of 2‐(aryl)‐3‐(3‐((8‐hydroxyquinolin‐5‐yl)diazenyl)phenyl)thiazolidin‐4‐ones

Synthesis, characterization, antibacterial and antifungal activity of 2‐(aryl)‐3‐(3‐((8‐hydroxyquinolin‐5‐yl)diazenyl)phenyl)thiazolidin‐4‐ones

Synthesis and synthetic applications of cyanoacetamides

Synthesis and Anticancer Evaluation of Some New Heterocyclic Scaffolds Incorporating the Acetanilide Moiety

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