Synthesis and antimicrobial of new anthraquinone derivatives incorporating pyrazole moiety

Synthesis, Biological Activity and Cytotoxicity of New Fused Pyrazolo[1,5-<i>a</i>]pyrimidine from 5-Aminopyrazole Incorporated with <i>p</i>-Chloroaniline

“…Several derivatives such as 4-hydroxypyrazolopyrimidine (allopurin), which are used in the treatment of hyperuricemia and gout, inhibit de novo purine biosynthesis and xanthine oxidase [8]. Cyclization of 5-aminopyrazoles with ketene-S,S and N,S-acetals is the most widely used route for the synthesis of pyrazolopyrimidines [9][10][11][12]. Accordingly, we report in this paper novel synthesis of functionalized pyrazolo [1, 5-a] pyrimidines 4a-b, 5a-c, 6 by the reactions of 5-aminopyrazole 3 with respective 2-[bis (methylthio)methylene]malononitrile 1, ethyl 2-cyano-3,3-bis[methylthio]acrylate, α, α-dicyanoketene-N, S-acetals 2a-c.…”

Pharmacologically potentials of hydrazonone containing compounds: a promising scaffold

“…Cholic acid based hydrazones [14] showed antibacterial activity against Escherichia faecalis and E. coli (Rasras et al, 2010). Anthraquinone based hydrazones [15] showed promising bacteriostatic activity against P. auriginosa (Gouda et al, 2010). Various benzyledinehydrazides [16] showed bactericidal activity against S. aureus ( .…”

Synthesis and Biological Evaluation of N- Pyrazolyl Derivatives and Pyrazolopyrimidine Bearing a Biologically Active Sulfonamide Moiety as Potential Antimicrobial Agent

“…Compounds (6) and (9), when reacted separately with different heterocyclic secondary amines, gave the corresponding desired products, (7a-d) and (10a-d), respectively, in good yields (Scheme 2). The treatment of ethyl 4-amino-3-(4-chlorophenyl)-1H-pyrazol-5-carboxylate (1) with thiophosgene gave the corresponding 3-isothiocyanat derivatives (11). The reactivity of isothiocyanate (11) towards nitrogen nucleophile was investigated.…”

“…The 1 H-NMR spectrum of compound (17) Finally, the coupling at the 7-oxo position of compound (15) with allyl bromide and bromoethyne give the O-alkylation products (19) and (21), respectively. The treatment of ethyl 4-amino-3-(4-chlorophenyl)-1H-pyrazol-5-carboxylate (1) with thiophosgene gave the corresponding 3-isothiocyanat derivatives (11). The reactivity of isothiocyanate (11) towards nitrogen nucleophile was investigated.…”

“…Pyrazole plays a unique role in drug discovery programs. Pyrazole derivatives are an important class of heterocyclic compounds showing a wide range of biological activities such as antimicrobial [9][10][11] (Figure 1). …”