Synthesis and Antimicrobial Properties of TiO&lt;SUB&gt;2&lt;/SUB&gt; and TiO&lt;SUB&gt;2&lt;/SUB&gt;: Cu Thin Films Synthesised by a Cost Effective Sol–Gel Process

Prasad, Rajendra; Endrino, José L.; Jain, Nishant Kumar; Reddy, G S N; Basavaraju, D.; Rao, K. Narasimha; Naveen, C. S.; Phani, A. R.

doi:10.1166/asem.2012.1184

Cited by 2 publications

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“…However, it is generally recognized that TiO 2 have poor antibacterial activity, so bactericides are suggested to be added to avoid bacterial infection. Since existing antibiotics can increase the acquired resistance of bacteria thus lower their clinical efficacy, an alternative therapeutic strategy that introduces inorganic bactericides such as silver, copper, or zinc into TiO 2 has been developed . They possess broad‐spectrum antibacterial property, high stability, and tolerable cytocompatibility below certain doses, so incorporate these bactericides into TiO 2 NTs may be a promising choice.…”

Section: Introductionmentioning

confidence: 99%

“…Since existing antibiotics can increase the acquired resistance of bacteria thus lower their clinical efficacy, 16 an alternative therapeutic strategy that introduces inorganic bactericides such as silver, copper, or zinc into TiO 2 has been developed. [17][18][19] They possess broad-spectrum antibacterial property, high stability, and tolerable cytocompatibility below certain doses, so incorporate these bactericides into TiO 2 NTs may be a promising choice. Through certain incorporative manner and doses, their antibacterial activity may be precisely controlled.…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial activity and cytocompatibility of Cu–Ti–O nanotubes

Hang

Gao

Huang

et al. 2013

J Biomedical Materials Res

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TiO2 nanotubes (NTs) have favorable biological properties, but the poor antibacterial activity limits their application especially in orthopedics fields. In this article, Cu-Ti-O nanotubes with different Cu contents are fabricated on sputtered TiCu films. Scanning electron microscopy reveals the NTs can be formed on sputtered TiCu films when the Cu content is less than 14.6 at %. X-ray photoelectron spectroscopy results indicate the NTs are consist of CuO mixed with TiO2 and the Cu content in NTs decreases dramatically compared with that in TiCu films. Biological experiments show that although these NTs have poor release antibacterial activity, their contact antibacterial activity has proven to be excellent, indicating the NT surface can effectively inhibit biomaterial-associated infections. The cytocompatibility of the NTs is closely related to the Cu content and when its content is relatively low (1.01 at %), there is no appreciable cytotoxicity. So Cu-Ti-O NTs with 1 at % Cu may be suitable to achieve proper antibacterial activity and desired cytocompatibility. The Cu-Ti-O NTs integrate the favorable antibacterial activity of Cu and excellent biological properties of TiO2 NTs therefore have potential applications in orthopedics, dentistry, and other biomedical fields.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antibacterial activity and cytocompatibility of Cu–Ti–O nanotubes

Hang

Gao

Huang

et al. 2013

J Biomedical Materials Res

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Functionalized TiO₂ Based Nanomaterials for Biomedical Applications

Weng

Liu

et al. 2014

Adv Funct Materials

239

115

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As baby boomers age, diabetes mellitus, cancer, osteoarthritis, cardiovascular diseases, and orthopedic disorders are more widespread and the demand for better biomedical devices and functional biomaterials is increasing rapidly. Owing to the good biocompatibility, chemical stability, catalytic efficiency, plasticity, mechanical properties, as well as strength‐to‐weight ratio, titanium dioxide (TiO2) based nanostructured materials are playing important roles in tissue reconstruction and diagnosis of these diseases. Here, recent advance in the research of nanostructured TiO2 based biomaterials pertaining to bone tissue engineering, intravascular stents, drug delivery systems, and biosensors is described.

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Synthesis and Antimicrobial Properties of TiO<SUB>2</SUB> and TiO<SUB>2</SUB>: Cu Thin Films Synthesised by a Cost Effective Sol–Gel Process

Cited by 2 publications

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Antibacterial activity and cytocompatibility of Cu–Ti–O nanotubes

Antibacterial activity and cytocompatibility of Cu–Ti–O nanotubes

Functionalized TiO₂ Based Nanomaterials for Biomedical Applications

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Synthesis and Antimicrobial Properties of TiO<SUB>2</SUB> and TiO<SUB>2</SUB>: Cu Thin Films Synthesised by a Cost Effective Sol–Gel Process

Cited by 2 publications

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Antibacterial activity and cytocompatibility of Cu–Ti–O nanotubes

Antibacterial activity and cytocompatibility of Cu–Ti–O nanotubes

Functionalized TiO2 Based Nanomaterials for Biomedical Applications

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Functionalized TiO₂ Based Nanomaterials for Biomedical Applications