Synthesis and Antimicrobial Screening of Some Fluorinated Azoles Containing (2-(6-Methyl-2-P-tolyl-lH-imidazo[1,2-a]pyridin-3-yl) Nucleus

Abstract

ABSTRACT. The synthesis of a series of fluorinated thiadiazoles 3, triazoles 4 and oxadiazoles 5 are synthesized from thiosemicarbazides 2 containing (2-(6-methyl-2-p-tolyl-lH-imidazo[1,2-a]pyridin-3-yl nucleus. These reactions were carried out by conventional method as well as ultra sound irradiation method. All products have been characterized by IR, 1 H NMR, MS study and screened for their antimicrobial activity.

Synthesis and biological evaluation of 1,2,4-triazoloazines as potent anticancer agents

“…11 Derivatives of 1,2,4-triazole and their fused systems occupy a prominent position among the promising compounds in medicinal chemistry. 7,12 These compounds have demonstrated notable antibacterial, 13,14 antifungal, 15 anticancer 16,17 and antiviral 18 activities. For instance, pyrazolo [4,3-e] [1,2,4]triazolopyrimidine 1 exhibited excellent activity against HCC1937 and HeLa cells.…”

Synthesis and Antibacterial Screening of Novel Fluorine Containing Heterocycles

“…High electronegativity and small size of fluorine can offer noticeable changes in bioactivities of a molecule. Much of the current research is concentrated towards fluorinated compounds due to their broad bioactivity spectrum [40][41][42][43] .…”