Synthesis and Antimicrobial Studies of New Trifluoromethylpyrimidine Analogues

Abstract

This paper describes the synthesis of a new series of trifluoromethylpyrimidine and their potential antimicrobial evaluation. We have prepared 10 novel pyrimidine derivatives in high yields and short reaction time using microwave irradiation. Compounds 4a,b and 6a,b showed good antimicrobial activity against Gram-positive bacteria; Clostridium perfringens, Bacillus pumilus and Enterococcus faecalis. These compounds were found to be the most potent antimicrobials compared to ampicillin, tetracycline, and streptomycin that showed no activity against Enterococcus faecalis. Compounds 4a,b and 6a,b exhibited great antimicrobial potency against all tested bacteria strains at a MIC of 3.125-100 μg/mL whereas only 4a showed the antimicrobial activity against Gram-negative bacteria Klebsiella pneumonia with a MIC value 12.5 μg/mL.