Synthesis and Antimicrobial Study of Novel Schiff Bases and Metal Complexes

Thombal, Devidas U.; Mirgane, Sunil R.; Ambhure, Ram U.; Pawar, Rajendra P.; Ameta, K. L.

doi:10.14355/bab.2017.03.002

Cited by 5 publications

(4 citation statements)

References 5 publications

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“…Thus, the ability of antibiotics to kill or inhibit the growth of bacteria is may be through inhibition of a step in peptidoglycan synthesis by gram positive bacteria. 47,48 In the case of antibacterial activity against Gram-positive bacteria (S. aureus and Bacillus), all compounds were found to have activity ranged between high and moderate. Our results indicated that the compounds Z 3 C and Z 3 C' possessed the highest antibacterial activity against Gm +Ve (S. aureus) with an IZ of (20, 22, 23, 25 and 21, 22, 26, 30 mm) at concentrations of (5, 25, 125, 250 mg/mL), respectively.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Synthesis, Characterization, and Antioxidant, Antimicrobial and Toxic Properties of Novel Δ2 -1,3,4-thiadiazoline and Δ2 -1,3,4-selenadiazoline Derivatives

Al-Khazragie¹,

Al-Salami²,

Al-Fartosy³

2022

IJDDT

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Two new series of N-(4-acetyl-5-aryl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide and N-(4-acetyl-5-aryl-4,5-dihydro1,3,4-selenadiazol-2-yl)acetamide compounds (where aryl = 4-nitrophenyl, 4-hydroxy-3-methoxyphenyl, 3-ethoxy-4- hydroxyphenyl, 2-chloroquinolinyl, and 6-chloro-4-oxo-4H-chromenyl) were synthesized in good yields by heterocyclization of thiosemicarbazones (TSCs) and selenosemicarbazones (SSCs) with acetic anhydride, respectively. The new TSCs and SSCs compounds was prepared by condensation reaction of thiosemicarbazide and Selenosemicarbazide with aromatic aldehydes in acidic medium. The structures of newly synthesized 1,3,4-thiadiazoline (TDZs) and 1,3,4-selenadiazoline (SDZs) derivatives were characterized by the analytical and spectroscopic method such as IR, 1 H NMR, 13C NMR, mass spectra and elemental analysis. The purity of compound and evaluation of Rf value were determined by TLC. The toxicity of new compounds was assayed via the determination of their LD50 value by using Dixon’ s up and down method. The antibacterial activity of 1,3,4-thiadiazoline and 1,3,4-selenadiazoline compounds were tested in vitro against Staphylococcus aureus, Bacillus, Escherichia coli and Pseudomonas aeruginosa. Finally, antioxidant efficiency of all compounds were detected according to β-carotene bleaching method.

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Section: Antibacterial Activitymentioning

confidence: 99%

Synthesis, Characterization, and Antioxidant, Antimicrobial and Toxic Properties of Novel Δ2 -1,3,4-thiadiazoline and Δ2 -1,3,4-selenadiazoline Derivatives

Al-Khazragie¹,

Al-Salami²,

Al-Fartosy³

2022

IJDDT

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“…The results may give an indication about the moderate toxicity effect of the studied compounds and clinical change observed in the mice after giving different doses. The toxic observed in injected mice may be manifested in some behaviors such as tremors, straight tail, salivation, urination, lacrimation, defecation, shortness of breath, excitation, muscle fasciculations, capillary bulge, convulsions and also the tortuous reflex in some treatments, and finally death at high toxic doses, Table 2 [40][41].…”

Section: Biological Activitymentioning

confidence: 99%

Synthesis, Antimicrobial, Antioxidant, Toxicity and Anticancer Activity of a New Azetidinone, Thiazolidinone and Selenazolidinone Derivatives Based on Sulfonamide

2022

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A new series of azetidinone (Z2a-Z2e, Z2g), thiazolidinone and selenazolidinone derivatives (Z2B, Z2E, Z2B', Z2E') based on sulfonamide have been synthesized and characterized by different instrumental techniques, such as elemental analyses, FTIR, multinuclear NMR (1H, 13C) and mass spectrometry. The tested compound containing selenium (Z2E') was less toxic than its analogs containing sulfur (Z2E) based on the LD50 value determined by Dixon's up and down method. All compounds showed antibacterial properties, however, Z2E' was more active against Gram-negative bacteria: Escherichia coli and Pseudomonas aeruginosa than Gram-positive ones: Streptococcus aureus and Bacillus, with the lowest MIC value of 5 mg/mL. All compounds showed good antioxidant activity at a lower rate than the standard compound BHT (82%). More precisely, Z2b was the main compound that possess strong activity as an antioxidant (73%). MTT viability assay showed that all tested compounds had cytotoxic effects on MCF-7 cells after 72 h of treatment. Our results revealed that Z2E' and Z2E compounds possessed strong activity (IC50 = 24.8 and 90.9 µg/mL, respectively) against MCF-7 cells at a higher rate than the standard compound 5-FU (IC50 = 97.47 µg/mL). Our results indicated that Z2E' had a promising bioactive scaffold of great medicinal interest due to their numerous pharmacological and biological activities.

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“…Thus the ability of antibiotics to kill or inhibit the growth of bacteria is may be through inhibition of a step in peptidoglycan synthesis by gram positive bacteria. [42,43] In the case of antibacterial activity against Grampositive bacteria (Staphylococcus aureus and Bacillus), all compounds were found to have activity ranged between high and moderate. Our results indicated that the compound Z5A11'possessed the highest antibacterial activity against Gm+Ve (Staphylococcus aureus) with an IZ of (10, 23, 29, 30, and 31 mm) at concentrations of (1, 5, 25, 125, 250 mg/mL).…”

Section: Antibacterial Activitymentioning

confidence: 99%

Synthesis, characterization and biological Activity of β-Lactam and Thiazolidinone Derivatives Based on Sulfonamide

et al. 2021

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Several new and know sulfonamide Schiff bases were prepared by the condensation reaction of sulfonamide (i.e.2-amino-4chlorobenzenesulfonamide, sulfamerazine, sulfanilamide, sulfamethazine, sulfathiazole and sulfadiazine) with vanillin and salicylaldehyde, respectively in an acidic medium. These Schiff bases were used to a new series of β-lactam (azetidin-2-one) compounds (i.e. 4-chloro-2-(2-(4-hydroxy-3-methoxyphenyl)-3-mercapto-4-oxoazetidin-1-yl)benzenesulfonamide , 4-[2-aryl-3-mercapto (or 3-hydroseleno)-4-oxoazetidin-1-yl]-N-substituted benzenesulfonamide; Z5A1-Z5A6, Z5A9-Z5A12, Z5A2', Z5A9'-Z5A11') by their reactions with thioglycolic acid and 2-seleno-glycolic acid, respectively, in presences of phosphorus oxychloride and triethylamine. Cyclocondensation of the Schiff bases with 2-mercaptobutanoic acid in presence of zinc chloride afforded 4-thiazolidinone derivatives (i.e. 4-[5-ethyl-2-aryl-4-oxothiazolidin-3-yl]-N-substituted benzenesulfonamide; ZZ5A2-ZZ5A6, ZZ5A9-ZZ5A12). All new azetidin-2-one and 1,3-thiazolidin-4-onederivatives were characterized by IR, 1 H NMR, 13 C NMR, mass spectroscopic techniques and elemental analysis. The toxicity of new compounds was assayed via the determination of their LD50 value by using Dixon ' s up and down method. The antibacterial activity of azetidin-2-onecompounds were tested in vitro against Staphylococcus aureus, Bacillus, Escherichia coli and Pseudomonas aeruginosa. Furthermore, the antioxidant and anticancer efficiency of compounds were evaluated.

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Synthesis and Antimicrobial Study of Novel Schiff Bases and Metal Complexes

Cited by 5 publications

References 5 publications

Synthesis, Characterization, and Antioxidant, Antimicrobial and Toxic Properties of Novel Δ2 -1,3,4-thiadiazoline and Δ2 -1,3,4-selenadiazoline Derivatives

Synthesis, Characterization, and Antioxidant, Antimicrobial and Toxic Properties of Novel Δ2 -1,3,4-thiadiazoline and Δ2 -1,3,4-selenadiazoline Derivatives

Synthesis, Antimicrobial, Antioxidant, Toxicity and Anticancer Activity of a New Azetidinone, Thiazolidinone and Selenazolidinone Derivatives Based on Sulfonamide

Synthesis, characterization and biological Activity of β-Lactam and Thiazolidinone Derivatives Based on Sulfonamide

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