Aromatic Fused heterocycles containing Nitrogen (N) and Sulfur(S) has extraordinary bioactive behavior due to which they are attracting the interest of chemists worldwide & thus used as a potential material in medicinal/pharmaceutical industries. The nitrogen-sulphur fused heterocycles attracting attention of the researchers due to number of biological and pharmacological activities and observed to exhibit extensive applications in drug discovery and development. The efforts are made to understand biological activity based on position of heteroatom & the substituent present in 5-member aromatic heterocyles. These compounds reported to having anticancer, anticonvulsant, antimicrobial, and antitubercular activities. This chapter aims to provide comprehensive overview on their hidden potential and inspiring further exploration into their biological relevance with respect to thiazolo thiadiazole & thiazolo thiazole derivatives are possessing considerable prospects in the field of drug development & material Science.