Synthesis and Antioxidant Activity of Bis and Tris Heterocycles

Basha, Nabhubygari Mahaboob; Seenaiah, Dandu; Padmaja, A.; Padmavathi, V.; Bhargav, Desaraju Suresh; Vijaya, Tartte

doi:10.1002/ardp.201300290

Cited by 10 publications

(3 citation statements)

References 45 publications

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“…In fact, we have reported the synthesis of multifunctional 1,3,4‐oxadiazoles, 1,3,4‐thiadiazoles, and 1,2,4‐triazoles via potassium salt of different acid hyrazides . We have also reported these heterocycles from various acids and acid hydrazides followed by interconversion in the presence of appropriate nucleophiles . Encouraged by these results and our continued interest in the development of a variety of heterocycles with different pharmacophore unit, the present work has been taken up.…”

Section: Introductionmentioning

confidence: 91%

Synthesis of Symmetrical Bis(5‐substituted oxadiazolyl/thiadiazolyl/triazolylmethyl)sulfones

Adivireddy¹,

Pedamalakondaiah²,

Gopala³

et al. 2016

Journal of Heterocyclic Chem

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Section: Introductionmentioning

confidence: 91%

Synthesis of Symmetrical Bis(5‐substituted oxadiazolyl/thiadiazolyl/triazolylmethyl)sulfones

Adivireddy¹,

Pedamalakondaiah²,

Gopala³

et al. 2016

Journal of Heterocyclic Chem

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“…Besides synthesis and biological experiments, computational studies are becoming the crucial tool in organic research focusing on structure orientation, compound behavior, molecular properties prediction, ligand–protein interactions, binding energies, and others [ 21 ]. In recent years, numerous results related to machine-assisted studies combined with synthetic research have been published [ 22 , 23 , 24 , 25 , 26 ]. As far as we are aware, there are currently no reports combining information about DHP, its environmentally friendly manufacturing method, biological properties, and computer simulations.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic and Infection-Controlled Investigations of Novel Dihydropyridine Hybrids: An Efficient Synthesis and Molecular-Docking Studies

et al. 2023

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A sequence of novel 1,4-dihydropyridines (DHP) and their hybrids was developed using a multicomponent strategy under environmentally benign conditions. In addition, computational studies were performed, and the ligand–protein interactions calculated in different bacteria and two fungal strains. Para-hydroxy-linked DHP (5f) showed the best binding energies of 3.591, 3.916, 8.499 and 6.895 kcal/mol against various pathogens used and other substances received a good docking score. The pathogen resistance potential of the synthesized targets against four bacteria and two fungi showed that whole DHP substances exhibit different levels of resistance to each microorganism. Gram-positive bacteria, which are highly sensitive to all molecules, and the MTCC-1884-encoded fungus strongly rejected the studied compounds compared to comparator drugs. In particular, the 5f candidate showed remarkable antimicrobial activity, followed by the substances 5a, 5b, 5j, 5k and 5l. Furthermore, MIC and MBC/MFC properties showed that 5f had a minimum bacterial concentration of 12.5 μg/mL against E. coli and against two fungal pathogens, with its killing activity being effective even at low concentrations. On the other hand, whole motifs were tested for their cytotoxic activity, revealing that the methoxy and hydroxy-linked compounds (5h) showed greater cytotoxic potency, followed by the two hydroxy linked compounds (5d and 5f). Overall, this synthetic approach used represents a prototype for future nature-favored synthesis methods and these biological results serve as a guide for future therapeutic drug research. However, the computer results play an important role in the further development of biological experiments.

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“…On the other hand, the chemistry of heterocycles is an integrating part of chemical sciences which represent a considerable part of modernity and form an important class of organic components. In recent years, several research works have been devoted to the synthesis of bis‐heterocyclic compounds because they have antioxidant, antitumor, anticancer, and antidepressants activities . Moreover, organophosphorus has received much attention due to their broad spectrum of biological activities such as antimicrobial, cytotoxic, and antiviral agents .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Evaluation of New Bis‐1,3,4,2‐triazaphospholinoalkane Derivatives as In Vitro α‐Amylase and Lipase Inhibitors

Hamzaoui

Salah

Hamden

et al. 2015

Archiv der Pharmazie

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A series of new 1,ω-bis-(5-alkyl-2-oxide-3-tosyl-1,3,4,2-triazaphospholino)alkanes 2 and 3 were prepared in good yields by the treatment of 1,ω-bis-(1-tosylamidrazone)alkanes 1 with two molar equivalents of phosphoryl trichloride and phenylphosphonic dichloride, respectively. All the newly synthesized compounds were characterized by IR, (1) H NMR, (13) C NMR, (31) P NMR, and elemental analysis. All the new compounds were screened for their inhibitory effect on the key enzymes related to diabetes and obesity, as α-amylase and lipase. The in vitro study revealed that these alkane derivatives exert an inhibitory action against these key enzymes, especially 2b with an IC50 of 16 μg/mL against α-amylase and lipase. Overall, the findings of the current study indicate that 2d exhibits attractive properties and can therefore be considered for future application in the development of antidiabetic and hypolipidemic drugs.

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Synthesis and Antioxidant Activity of Bis and Tris Heterocycles

Cited by 10 publications

References 45 publications

Synthesis of Symmetrical Bis(5‐substituted oxadiazolyl/thiadiazolyl/triazolylmethyl)sulfones

Synthesis of Symmetrical Bis(5‐substituted oxadiazolyl/thiadiazolyl/triazolylmethyl)sulfones

Cytotoxic and Infection-Controlled Investigations of Novel Dihydropyridine Hybrids: An Efficient Synthesis and Molecular-Docking Studies

Synthesis and Evaluation of New Bis‐1,3,4,2‐triazaphospholinoalkane Derivatives as In Vitro α‐Amylase and Lipase Inhibitors

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